Global Patent Index - EP 1298127 A1

EP 1298127 A1 20030402 - AMINO ACID-N-CARBOXY ANHYDRIDES HVAING SUBSTITUENT AT NITROGEN

Title (en)

AMINO ACID-N-CARBOXY ANHYDRIDES HVAING SUBSTITUENT AT NITROGEN

Title (de)

AMINOSÄURE-N-CARBOXY-ANHYDRIDE MIT SUBSTITUENTEN AM STICKSTOFF

Title (fr)

ANHYDRIDES D'ACIDE-AMINO-N-CARBOXY PRESENTANT UN SUBSTITUANT A LA POSITION DE L'AZOTE

Publication

EP 1298127 A1 20030402 (EN)

Application

EP 01949905 A 20010704

Priority

  • JP 0105780 W 20010704
  • JP 2000201745 A 20000704
  • JP 2000303522 A 20001003

Abstract (en)

This invention provides amino acid N-carboxyanhydrides, each of which has an N-acyl substituent on its nitrogen atom, is represented by the following formula (1): <IMAGE> readily reacts with nucleophilic reagents such as free amino acids, alcohols, anions or the like, and are intermediates useful for the high-yield production of amino acid derivatives, optically active compounds, peptides, polypeptides and the like useful in many fields lead by the fields of pharmaceuticals and agrochemicals, and also provides a process for the production of the amino acid N-carboxyanhydrides. Further, the present invention also provides a process for the production of diamides, which uses the compounds of the formula (1) and amine derivatives represented by the following formula (7): <IMAGE> These diamides can also be suitably used for the production of amino acid derivatives, optically active compounds, peptides, polypeptides and the like.

IPC 1-7

C07D 263/44; C07D 413/06; C07D 417/06; C07D 471/04; C07D 471/08

IPC 8 full level

C07C 231/10 (2006.01); C07C 237/22 (2006.01); C07D 263/44 (2006.01); C07D 295/185 (2006.01); C07D 413/06 (2006.01); C07D 413/14 (2006.01); C07D 417/06 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 487/08 (2006.01); C07D 521/00 (2006.01)

CPC (source: EP)

C07C 231/10 (2013.01); C07C 237/22 (2013.01); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 249/08 (2013.01); C07D 263/44 (2013.01); C07D 295/185 (2013.01); C07D 413/06 (2013.01); C07D 413/14 (2013.01); C07D 417/06 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/08 (2013.01)

Designated contracting state (EPC)

DE FR GB IT

DOCDB simple family (publication)

US 2002173664 A1 20021121; US 6670447 B2 20031230; CN 1388804 A 20030101; EP 1298127 A1 20030402; EP 1298127 A4 20041208; WO 0202538 A1 20020110

DOCDB simple family (application)

US 7015602 A 20020304; CN 01802614 A 20010704; EP 01949905 A 20010704; JP 0105780 W 20010704