EP 1301498 A1 20030416 - COLCHINOL DERIVATIVES AS ANGIOGENESIS INHIBITORS
Title (en)
COLCHINOL DERIVATIVES AS ANGIOGENESIS INHIBITORS
Title (de)
COLCHINOLDERIVATE ALS HEMMSTOFF DER ANGIOGENESE
Title (fr)
DERIVES DE COLCHINOL UTILES COMME INHIBITEURS DE L'ANGIOGENESE
Publication
Application
Priority
- EP 01943701 A 20010704
- EP 00401977 A 20000707
- EP 00401976 A 20000707
- GB 0102964 W 20010704
Abstract (en)
[origin: WO0208213A1] The invention related to colchinol derivatives of the formula (I): Wherein: R<1>, R<2> and R<3> are each independently hydroxy, phosphoryloxy (-OPO3H2), C1-4alkoxy or an in vivo hydrolysable ester of hydroxy, with the proviso that at least 2 of R<1>, R<2> and R<3> are C1-4alkoxy; A is -CO-, -C(O)O-, -CON(R<8>)- (wherein R<8> is hydrogen, C1-4alkyl, C1-3alkoxyC1-3alkyl, aminoC1-3alkyl or hydroxyC1-3alkyl); a is an integer from 1 to 4 inclusive; R<a> and R<b> are independently selected from hydrogen, hydroxy and amino; B is -O-, -CO-, N(R<9>)CO-, -CON(R<9>)-, -N(R<9>)C(O)O-, -N(R<9>)CON(R<10>)-, -N(R<9>)SO2-, -SO2N(R<9>)- or a direct single blond (wherein R<9> and R<10> are independently selected from hydrogen, C1-4alkyl, C1-3alkoxyC1-3alkyl,aminoC1-3alkyl and hydroxyC1-3alkyl); b is O or an integer from 1 to 4 inclusive, (provided that when bis O, B is a single direct bond); D is carboxy, sulpho, tetrazolyl, imidazolyl, phosphoryloxy, hydroxy, amino, N-(C1-4alkyl)amino, N,N-di(C1-3alkyl)amino, or of the formula-Y<1>(CH2)0R<11> or -NHCH(R<12>)COOH;[wherein Y<1> is a direct single bond, -O-, -C(O)-, -N(R<13>)C(O)- or -C(O)N(R<13>)- (wherein R<13> is hydrogen, C1-4alkyl,C1-3alkoxyC2-3alkyl, aminoC2-3alkyl or hydroxyC2-3alkyl); e is O or an integer from 1 to 4 inclusive.
IPC 1-7
C07D 295/185; A61K 31/495; A61P 35/00; C07K 5/062; C07F 9/09; C07D 295/088; C07C 217/74; C07D 233/61
IPC 8 full level
A61K 31/167 (2006.01); A61K 31/417 (2006.01); A61K 31/495 (2006.01); A61K 31/5377 (2006.01); A61K 31/661 (2006.01); A61K 45/06 (2006.01); A61P 3/10 (2006.01); C07D 295/14 (2006.01); A61P 9/00 (2006.01); A61P 15/00 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07C 217/74 (2006.01); C07C 231/12 (2006.01); C07C 237/22 (2006.01); C07D 233/61 (2006.01); C07D 295/088 (2006.01); C07D 295/18 (2006.01); C07D 295/185 (2006.01); C07D 521/00 (2006.01); C07F 9/09 (2006.01); C07K 5/06 (2006.01); C07K 5/062 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP KR)
A61K 31/495 (2013.01 - EP); A61K 45/06 (2013.01 - EP); A61P 3/10 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 15/00 (2018.01 - EP); A61P 17/06 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 27/02 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07C 237/22 (2013.01 - EP); C07D 231/12 (2013.01 - EP); C07D 233/56 (2013.01 - EP); C07D 249/08 (2013.01 - EP); C07D 295/088 (2013.01 - EP); C07D 295/185 (2013.01 - EP KR); C07F 9/091 (2013.01 - EP); C07K 5/06026 (2013.01 - EP); A61K 38/00 (2013.01 - EP); C07C 2603/32 (2017.05 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0208213 A1 20020131; AU 2001266232 B2 20050915; AU 6623201 A 20020205; BR 0112225 A 20030506; CA 2410562 A1 20020131; CN 1255392 C 20060510; CN 1440396 A 20030903; CZ 200331 A3 20030416; EE 200300015 A 20041015; EP 1301498 A1 20030416; HU P0301742 A2 20030929; HU P0301742 A3 20050829; IL 153325 A0 20030706; IS 6668 A 20030103; JP 2004504391 A 20040212; KR 20030022264 A 20030315; MX PA02012903 A 20040730; NO 20030055 D0 20030106; NO 20030055 L 20030106; NZ 522661 A 20040730; PL 359181 A1 20040823; RU 2003103603 A 20040820; SK 52003 A3 20030701
DOCDB simple family (application)
GB 0102964 W 20010704; AU 2001266232 A 20010704; AU 6623201 A 20010704; BR 0112225 A 20010704; CA 2410562 A 20010704; CN 01812402 A 20010704; CZ 200331 A 20010704; EE P200300015 A 20010704; EP 01943701 A 20010704; HU P0301742 A 20010704; IL 15332501 A 20010704; IS 6668 A 20030103; JP 2002514119 A 20010704; KR 20037000098 A 20030104; MX PA02012903 A 20010704; NO 20030055 A 20030106; NZ 52266101 A 20010704; PL 35918101 A 20010704; RU 2003103603 A 20010704; SK 52003 A 20010704