EP 1301602 A2 20030416 - FH-BINDING PROTEIN OF STREPTOCOCCUS PNEUMONIAE

Title (en)

FH-BINDING PROTEIN OF STREPTOCOCCUS PNEUMONIAE

Title (de)

FH-BINDENDES PROTEIN AUS STREPTOCOCCUS PNEUMONIAE

Title (fr)

PROTEINE DE STREPTOCOCCUS PNEUMONIAC SE LIANT AU FACTEUR H

Publication

EP 1301602 A2 20030416 (EN)

Application

EP 01967212 A 20010719

Priority

EP 0108409 W 20010719
SE 0002728 A 20000720

Abstract (en)

[origin: CA2416657A1] The present invention provides proteins and peptides derived from Streptococcus pneumoniae, type 3, which bind the complement factor H (fH). These proteins and peptides show a homology of at least 50 %, preferably at least 60 %, and most preferably at least 70 % with the subsequence from Thr3 8 to Lys 149 of the sequence disclosed herein as SEQ ID NO:1. The above subsequence, which is located in the amino-terminal of a surface protein isolated from Streptococcus Pneumoniae, type 3, is highly associated with binding of fH. In another aspect, the invention relates to proteins and peptides showing a homology of at least 85 %, preferably at least 95 %, and most preferably at least 99 % with the Hic protein, the amino acid sequence of which is disclosed is SEQ ID NO:1. The invention also provides vaccine compositions comprising the above proteins and peptides.

IPC 1-7

C12N 15/31; C12N 15/63; C07K 14/315; C07K 16/12; A61K 31/711; A61K 39/09

IPC 8 full level

G01N 33/50 (2006.01); A61K 31/711 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/09 (2006.01); A61K 45/00 (2006.01); A61P 11/00 (2006.01); A61P 31/04 (2006.01); A61P 43/00 (2006.01); C07K 14/315 (2006.01); C07K 16/12 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/31 (2006.01); C12N 15/63 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01)

IPC 8 main group level

C07K (2006.01)

Citation (search report)

See references of WO 0208426A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

CA 2416657 A1 20020131; EP 1301602 A2 20030416; JP 2004504056 A 20040212

DOCDB simple family (application)

CA 2416657 A 20010719; EP 01967212 A 20010719; JP 2002513909 A 20010719