EP 1307135 A4 20060531 - SYSTEMS AND METHODS FOR PROVIDING INFORMATION CONCERNING CHROMOPHORES IN PHYSIOLOGICAL MEDIA
Title (en)
SYSTEMS AND METHODS FOR PROVIDING INFORMATION CONCERNING CHROMOPHORES IN PHYSIOLOGICAL MEDIA
Title (de)
SYSTEME UND VERFAHREN ZUR BEREITSTELLUNG VON INFORMATIONEN DIE CHROMOPHOREN IN PHYSIOLOGISCHEN MEDIEN BETREFFEN
Title (fr)
SYSTEMES ET PROCEDES PERMETTANT D'OBTENIR DES INFORMATIONS CONCERNANT DES CHROMOPHORES PRESENTS DANS DES MILIEUX PHYSIOLOGIQUES
Publication
Application
Priority
- US 0124301 W 20010803
- US 22281600 P 20000804
- US 22307400 P 20000804
- US 66497200 A 20000918
- US 77861401 A 20010206
- US 77861801 A 20010206
- US 77861701 A 20010206
- US 77861301 A 20010206
- US 87751501 A 20010607
Abstract (en)
[origin: WO0212854A2] The present invention generally relates to systems and methods for providing information about chromophores in physiological media. More particularly, the invention relates to non-invasive systems and methods for determining absolute values of oxygenated and/or deoxygenated hemoglobins and their ratios in a physiological medium. The system in a preferred embodiment generally includes a portable probe having a source module for irradiating into the medium electromagnetic radiation, a detector module detecting radiation from a target area in the medium, and a processing module determining the absolute values of the chromophore concentrations and their ratios thereof based on input and output parameters of the source and detector modules. In one aspect, the invention provides a solution for the unknown paramters of the chromophores in a medium using a novel processing algorithm. In another aspect, the invention concerns a portable unit for performing the requisite measurements, which unit includes a movable member having one or more radiation sources and one or more radiation detectors, and an actuator designed to cause the member to move along predetermined curvilinear paths. Properties of the chromophores are measured for individual voxels defined along each motion path, and/or cross-voxels defined at the intersection of voxels along different motion paths. These measured values are then used in a preferred embodiment to generate two- or three-dimensional images of the distribution of chromophores or their properties. In other aspects, the invention includes various patterns for the optimal distribution of sources and detectors for the optical probe, and self-calibrating operation of the probe substantially in real-time.
IPC 1-7
IPC 8 full level
A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01); C12Q 1/04 (2006.01); G01N 21/27 (2006.01); G01N 21/33 (2006.01); G01N 21/35 (2006.01); G01N 33/48 (2006.01); G01N 33/483 (2006.01); G01N 33/72 (2006.01); G06F 17/10 (2006.01); G01N 21/31 (2006.01); G01N 21/49 (2006.01)
CPC (source: EP)
A61B 5/14546 (2013.01); A61B 5/14551 (2013.01); A61B 5/14552 (2013.01); A61B 5/14553 (2013.01); A61B 5/413 (2013.01); A61B 2562/0233 (2013.01); A61B 2562/0242 (2013.01); A61B 2562/043 (2013.01); A61B 2562/046 (2013.01); G01N 21/359 (2013.01); G01N 21/49 (2013.01); G01N 2021/3144 (2013.01)
Citation (search report)
- [X] US 6078833 A 20000620 - HUEBER DENNIS M [US]
- [X] US 5517987 A 19960521 - TSUCHIYA YUTAKA [JP]
- [X] US 5057695 A 19911015 - HIRAO KONOMU [JP], et al
- [DA] MICHAEL NEUMAN: "PULSE OXIMETRY: PHYSICAL PRONCIPLES, TECHNICAL REALIZATION AND PRESENT LIMITATIONS", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 220, 1987, pages 135 - 144, XP009059615
- See references of WO 0212854A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0212854 A2 20020214; WO 0212854 A3 20021219; WO 0212854 A9 20021017; AU 8100501 A 20020218; CA 2417917 A1 20020214; CA 2417917 C 20141014; EP 1307135 A2 20030507; EP 1307135 A4 20060531
DOCDB simple family (application)
US 0124301 W 20010803; AU 8100501 A 20010803; CA 2417917 A 20010803; EP 01959449 A 20010803