EP 1307442 A2 20030507 - METHOD FOR PRODUCING LIPOIC ACID AND DIHYDROLIPOIC ACID
Title (en)
METHOD FOR PRODUCING LIPOIC ACID AND DIHYDROLIPOIC ACID
Title (de)
VERFAHREN ZUR HERSTELLUNG VON LIPONSÄURE UND DIHYDROLIPONSÄURE
Title (fr)
PROCEDE DE PRODUCTION D'ACIDE LIPOIQUE ET D'ACIDE DIHYDROLIPOIQUE
Publication
Application
Priority
- DE 10038038 A 20000802
- DE 10044000 A 20000905
- EP 0108523 W 20010724
Abstract (en)
[origin: WO0210151A2] The invention relates to a method for producing R-lipoic acid and S-lipoic acid comprising a step selected from the following: (a) distillation of dihydrolipoic acid, (b) reaction of (2) or the stereoisomer thereof, wherein Ms represents SO2-R', and R and R' independently mean C1-C6-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulphide and sulphur in ethanol and reaction with a complex hydride, (c) extraction of a protic solution of R dihydrolipoic acid or S-dihydrolipoic acid with an organic solvent at a pH value of 9 -10, or (d) extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with an organic solvent from a protic solution at a pH value of 4 - 5, or a combination of individual or several steps (a) - (d). The invention also relates to a method for producing dihydrolipoic acid and the compound 1,6,8 octane triol.
IPC 1-7
IPC 8 full level
A61K 31/20 (2006.01); A61P 3/10 (2006.01); C07B 53/00 (2006.01); C07C 303/38 (2006.01); C07C 319/08 (2006.01); C07C 319/18 (2006.01); C07C 319/28 (2006.01); C07C 321/04 (2006.01); C07C 323/52 (2006.01); C07D 339/04 (2006.01); C07C 309/66 (2006.01)
CPC (source: EP US)
A61P 3/10 (2017.12 - EP); C07C 319/18 (2013.01 - EP US); C07C 321/04 (2013.01 - EP US); C07D 339/04 (2013.01 - EP US)
Citation (search report)
See references of WO 0210151A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0210151 A2 20020207; WO 0210151 A3 20021114; AR 030108 A1 20030813; AU 9167701 A 20020213; BR 0112848 A 20030624; CA 2417842 A1 20030130; CN 1218945 C 20050914; CN 1444580 A 20030924; CN 1680364 A 20051012; EP 1307442 A2 20030507; JP 2004509856 A 20040402; TW 200519076 A 20050616; US 2004044227 A1 20040304; US 6906210 B2 20050614
DOCDB simple family (application)
EP 0108523 W 20010724; AR P010103687 A 20010802; AU 9167701 A 20010724; BR 0112848 A 20010724; CA 2417842 A 20010724; CN 01813578 A 20010724; CN 200510008864 A 20010724; EP 01971775 A 20010724; JP 2002515882 A 20010724; TW 94102573 A 20010802; US 34303403 A 20030127