EP 1307452 A1 20030507 - USE OF POLYCYCLIC AROMATIC COMPOUNDS FOR MAKING MEDICINES CAPABLE OF INHIBITING TELOMERASE

Title (en)

USE OF POLYCYCLIC AROMATIC COMPOUNDS FOR MAKING MEDICINES CAPABLE OF INHIBITING TELOMERASE

Title (de)

VERWENDUNG VON POLYCYCLISCHEN AROMATISCHEN VERBINDUNGEN ZUR HERSTELLUNG VON ARZNEIMITTELN ALS TELOMERASE INHIBITOREN

Title (fr)

UTILISATION DE COMPOSES AROMATIQUES POLYCYCLIQUES POUR FABRIQUER DES MEDICAMENTS CAPABLES D'INHIBER LA TELOMERASE

Publication

EP 1307452 A1 20030507 (FR)

Application

EP 01958203 A 20010730

Priority

FR 0102492 W 20010730
FR 0010218 A 20000802

Abstract (en)

[origin: WO0210165A1] The invention concerns the use of aromatic compounds capable of binding with G-quadruplex structures to produce medicines with anti-telomerase effect. Said compounds correspond to formula (I) wherein: R1, R2 and R3, identical or different, represent a hydrogen atom, or a -CH2-NH-(CH2)n-X group, wherein n is an integer from 2 to 4, and X is selected among -NH2-, -N(CH3)2 radicals, a heterocyclic radical such as piperidyl, imidazolyl, morpholinyl radical, or an indole-type condensed heterocyclic radical, -Z represents CH or N, each compound comprising two nitrogen atoms in the Z positions. The invention is useful for producing anticancer medicines.

IPC 1-7

C07D 471/04; A61K 31/4375; A61P 35/00; C07D 221/00

IPC 8 full level

A61K 31/4745 (2006.01); A61K 31/498 (2006.01); A61K 31/4985 (2006.01); A61K 31/5377 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01)

CPC (source: EP US)

A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 471/04 (2013.01 - EP US)

Citation (search report)

See references of WO 0210165A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0210165 A1 20020207; CA 2417473 A1 20020207; EP 1307452 A1 20030507; FR 2812634 A1 20020208; FR 2812634 B1 20021108; JP 2004505082 A 20040219; US 2004034023 A1 20040219

DOCDB simple family (application)

FR 0102492 W 20010730; CA 2417473 A 20010730; EP 01958203 A 20010730; FR 0010218 A 20000802; JP 2002515894 A 20010730; US 34361603 A 20030715