EP 1308462 A1 20030507 - HEPATITIS B VIRUS (HBV) ANTIGENIC POLYPEPTIDE-HEAT SHOCK PROTEIN COMPLEX AND USE THEREOF
Title (en)
HEPATITIS B VIRUS (HBV) ANTIGENIC POLYPEPTIDE-HEAT SHOCK PROTEIN COMPLEX AND USE THEREOF
Title (de)
POLYPEPTID-KOMPLEX AUS HEPATITIS-B-VIRUS (HBV)-ANTIGEN UND HITZESCHOCKPROTEIN UND SEINE VERWENDUNG
Title (fr)
ANTIGENE DU VIRUS DE L'HEPATITE B ASSOCIE AU COMPLEXE PROTEIQUE DE CHOC THERMIQUE ET SON UTILISATION
Publication
Application
Priority
- CN 0100295 W 20010227
- CN 00121270 A 20000811
- CN 01104060 A 20010220
Abstract (en)
The present invention provides a kind of HBV-antigen bound to heat shock proteins(hsps) which comprises core antigen, surface antigen and polymerase antigen. The present invention also provides a complex of HBV antigen bound to heat shock protein gp96 and hsp78, as well as a method for preparing the complex. The complex includes a complex of gp96 and hsp78 non-covalently bound to antigenic polypeptide, as well as a fusion protein of both which results from covalent binding. Such complex can be used to prepare therapeutic vaccine for treating hepatitis B and primary hepatocellular carcinoma.
IPC 1-7
IPC 8 full level
A61K 39/29 (2006.01); A61P 1/16 (2006.01); A61P 31/20 (2006.01); A61P 35/00 (2006.01); C07K 14/02 (2006.01); C07K 14/47 (2006.01); C07K 19/00 (2006.01)
CPC (source: EP US)
A61K 39/12 (2013.01 - EP US); A61K 39/292 (2013.01 - EP US); A61P 1/16 (2017.12 - EP); A61P 31/20 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07K 14/005 (2013.01 - EP US); A61K 2039/6043 (2013.01 - EP US); A61K 2039/622 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US); C12N 2730/10122 (2013.01 - EP US); C12N 2730/10134 (2013.01 - EP US)
Citation (search report)
See references of WO 0214370A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0214370 A1 20020221; AU 4633101 A 20020225; CN 1107681 C 20030507; CN 1316431 A 20011010; EP 1308462 A1 20030507; JP 2004506045 A 20040226; US 2004047879 A1 20040311; US 7247712 B2 20070724
DOCDB simple family (application)
CN 0100295 W 20010227; AU 4633101 A 20010227; CN 01104060 A 20010220; EP 01919092 A 20010227; JP 2002519507 A 20010227; US 34450203 A 20030728