Global Patent Index - EP 1309718 A4

EP 1309718 A4 20040825 - NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT

Title (en)

NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT

Title (de)

NEUTROKIN-ALPHA UND SPLEISS-VARIANTEN VON NEUTROKIN-ALPHA

Title (fr)

NEUTROKINE-ALPHA ET VARIANT D'EPISSAGE DE NEUTROKINE-ALPHA

Publication

EP 1309718 A4 20040825 (EN)

Application

EP 01967981 A 20010815

Priority

  • US 0125549 W 20010815
  • US 22562800 P 20000815
  • US 22700800 P 20000823
  • US 23433800 P 20000922
  • US 24080600 P 20001017
  • US 25002000 P 20001130
  • US 27624801 P 20010316
  • US 29349901 P 20010525
  • US 29612201 P 20010607
  • US 30480901 P 20010713

Abstract (en)

[origin: WO0218620A2] The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.

IPC 1-7

C07K 14/705; A61K 38/19; A61K 51/08

IPC 8 full level

A61K 47/48 (2006.01); A61K 49/00 (2006.01); C07K 14/52 (2006.01); C07K 16/24 (2006.01); C12N 15/12 (2006.01); C12N 15/13 (2006.01); G01N 33/564 (2006.01)

CPC (source: EP)

A61K 47/6849 (2017.07); A61K 49/0004 (2013.01); A61P 35/00 (2017.12); A61P 37/00 (2017.12); C07K 14/52 (2013.01); C07K 16/24 (2013.01); G01N 33/564 (2013.01); C07K 2317/21 (2013.01); C07K 2317/622 (2013.01)

Citation (search report)

  • [A] WO 9818921 A1 19980507 - HUMAN GENOME SCIENCES INC [US], et al
  • [A] WO 9827114 A2 19980625 - SCHERING CORP [US]
  • [A] WO 9912964 A2 19990318 - BIOGEN INC [US], et al
  • [Y] HEPPELER A ET AL: "RECEPTOR TARGETING FOR TUMOR LOCALISATION AND THERAPY WITH RADIOPEPTIDES", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 9, no. 7, 2000, pages 971 - 994, XP000982225, ISSN: 0929-8673
  • [Y] SCHNEIDER P ET AL: "BAFF, A NOVEL LIGAND OF THE TUMOR NECROSIS FACTOR FAMILY, STIMULATES B CELL GROWTH", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 189, no. 11, 7 June 1999 (1999-06-07), pages 1747 - 1756, XP000915409, ISSN: 0022-1007
  • [A] MOORE P A ET AL: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 285, no. 5425, 9 July 1999 (1999-07-09), pages 260 - 263, XP002142252, ISSN: 0036-8075
  • [A] SHU H-B ET AL: "TALL-1 IS A NOVEL MEMBER OF THE TNF FAMILY THAT IS DOWN-REGULATED BY MITOGENS", JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL, US, vol. 65, no. 5, May 1999 (1999-05-01), pages 680 - 683, XP000939092, ISSN: 0741-5400
  • [T] YU G ET AL: "APRIL AND TALL-I AND RECEPTORS BCMA AND TACI: SYSTEM FOR REGULATING HUMORAL IMMUNITY", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP,, GB, vol. 1, no. 3, September 2000 (2000-09-01), pages 252 - 256, XP000982268, ISSN: 1529-2908
  • [T] KARPUSAS M ET AL: "Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 315, no. 5, 1 February 2002 (2002-02-01), pages 1145 - 1154, XP004470833, ISSN: 0022-2836
  • [T] LIU YINGFANG ET AL: "Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands", CELL, vol. 108, no. 3, 8 February 2002 (2002-02-08), pages 383 - 394, XP002286032, ISSN: 0092-8674
  • [T] OREN DEENA A ET AL: "Structural basis of BLyS receptor recognition.", NATURE STRUCTURAL BIOLOGY, vol. 9, no. 4, April 2002 (2002-04-01), pages 288 - 292, XP002286033, ISSN: 1072-8368 (ISSN print)
  • [A] DENARDO G L ET AL: "Comparison of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''tetraacetic acid (DOTA)-peptide-ChL6, a novel immunoconjugate with catabolizable linker, to 2-iminothiolane-2[p-(bromoacetamido)benzyl]-DOTA-ChL6 in breast cancer xenografts", CLINICAL CANCER RESEARCH 1998 UNITED STATES, vol. 4, no. 10, 1998, pages 2483 - 2490, XP001181898, ISSN: 1078-0432 & DATABASE UNIPROT [online] 16 October 2001 (2001-10-16), "Tumor necrosis factor ligand superfamily member 13B", XP002286038, retrieved from UNIPROT Database accession no. Q9Y275
  • See references of WO 0218620A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0218620 A2 20020307; WO 0218620 A3 20030320; AU 8826001 A 20020313; CA 2419661 A1 20020307; EP 1309718 A2 20030514; EP 1309718 A4 20040825

DOCDB simple family (application)

US 0125549 W 20010815; AU 8826001 A 20010815; CA 2419661 A 20010815; EP 01967981 A 20010815