EP 1311280 A2 20030521 - CELL INTERNALIZED PEPTIDE-DRUG CONJUGATES
Title (en)
CELL INTERNALIZED PEPTIDE-DRUG CONJUGATES
Title (de)
PEPTID-WIRKSTOFF-KONJUGATE IM ZELLINNERN
Title (fr)
CONJUGUES PEPTIDES-MEDICAMENTS INTEGRES DANS DES CELLULES
Publication
Application
Priority
- US 0124088 W 20010801
- US 62971900 A 20000801
Abstract (en)
[origin: WO0209649A2] Peptides which bind to leukocytes are conjugated with drugs. Advantageously, the peptide-drug conjugates interfere with ICAM-1/LFA-1 interactions and are internalized by leukocytes, whereby the drug portion of the conjugate exerts potent toxic side effects against targeted cells with minimal adverse side effects. Preferred conjugates include 4-30 mer peptides derived from ICAM-1 or LFA-1 coupled with drugs effective against leukocyte-related diseases.
IPC 1-7
IPC 8 full level
A61K 47/42 (2006.01); A61K 47/48 (2006.01); C07K 5/09 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01)
CPC (source: EP)
A61K 47/62 (2017.07)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0209649 A2 20020207; WO 0209649 A3 20020411; WO 0209649 A8 20020801; AU 7811301 A 20020213; CA 2417885 A1 20020207; EP 1311280 A2 20030521; EP 1311280 A4 20050223; JP 2004505029 A 20040219
DOCDB simple family (application)
US 0124088 W 20010801; AU 7811301 A 20010801; CA 2417885 A 20010801; EP 01956077 A 20010801; JP 2002515204 A 20010801