Global Patent Index - EP 1311280 A4

EP 1311280 A4 20050223 - CELL INTERNALIZED PEPTIDE-DRUG CONJUGATES

Title (en)

CELL INTERNALIZED PEPTIDE-DRUG CONJUGATES

Title (de)

PEPTID-WIRKSTOFF-KONJUGATE IM ZELLINNERN

Title (fr)

CONJUGUES PEPTIDES-MEDICAMENTS INTEGRES DANS DES CELLULES

Publication

EP 1311280 A4 20050223 (EN)

Application

EP 01956077 A 20010801

Priority

  • US 0124088 W 20010801
  • US 62971900 A 20000801

Abstract (en)

[origin: WO0209649A2] Peptides which bind to leukocytes are conjugated with drugs. Advantageously, the peptide-drug conjugates interfere with ICAM-1/LFA-1 interactions and are internalized by leukocytes, whereby the drug portion of the conjugate exerts potent toxic side effects against targeted cells with minimal adverse side effects. Preferred conjugates include 4-30 mer peptides derived from ICAM-1 or LFA-1 coupled with drugs effective against leukocyte-related diseases.

IPC 1-7

A61K 38/03; C07K 2/00; C07K 19/00

IPC 8 full level

A61K 47/42 (2006.01); A61K 47/48 (2006.01); C07K 5/09 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01)

CPC (source: EP)

A61K 47/62 (2017.07)

Citation (search report)

  • [Y] WO 9528170 A1 19951026 - UNIV KANSAS [US], et al
  • [Y] WO 9741149 A1 19971106 - UNIV KANSAS [US]
  • [X] SIAHAAN T J ET AL: "UTILIZATION OF CELL-ADHESION PEPTIDES TO IMPROVE DRUG DELIVERY", PEPTIDES FOR THE NEW MILLENNIUM. PROCEEDINGS OF THE AMERICAN PEPTIDE SYMPOSIUM, XX, XX, 1999, pages 209 - 211, XP001034997
  • [T] ANDERSON MEAGAN E ET AL: "Targeting ICAM-1/LFA-1 interaction for controlling autoimmune diseases: Designing peptide and small molecule inhibitors.", PEPTIDES (NEW YORK), vol. 24, no. 3, March 2003 (2003-03-01), pages 487 - 501, XP002290396, ISSN: 0196-9781
  • See references of WO 0209649A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0209649 A2 20020207; WO 0209649 A3 20020411; WO 0209649 A8 20020801; AU 7811301 A 20020213; CA 2417885 A1 20020207; EP 1311280 A2 20030521; EP 1311280 A4 20050223; JP 2004505029 A 20040219

DOCDB simple family (application)

US 0124088 W 20010801; AU 7811301 A 20010801; CA 2417885 A 20010801; EP 01956077 A 20010801; JP 2002515204 A 20010801