EP 1311532 B1 20090415 - OESTROGEN-17-SULPHAMATES AS INHIBITORS OF STEROID SULPHATASE
Title (en)
OESTROGEN-17-SULPHAMATES AS INHIBITORS OF STEROID SULPHATASE
Title (de)
ESTROGEN-17-SULPHAMATE ZUR HEMMUNG VON STEROID SULFATASE
Title (fr)
SULFAMATES D'OESTROGENE-17 EN TANT QU'INHIBITEURS DE STEROIDE SULFATASE
Publication
Application
Priority
- GB 0103688 W 20010817
- GB 0020498 A 20000818
Abstract (en)
[origin: EP2202240A1] There is provided a compound of Formula I wherein X is a ring system; R 1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R 2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R 1 and R 2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII wherein R 2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
IPC 8 full level
A61K 31/56 (2006.01); C07J 41/00 (2006.01); A61K 31/37 (2006.01); A61K 31/565 (2006.01); A61K 31/566 (2006.01); A61K 31/567 (2006.01); A61K 31/569 (2006.01); A61K 45/00 (2006.01); A61P 1/00 (2006.01); A61P 1/02 (2006.01); A61P 1/04 (2006.01); A61P 1/14 (2006.01); A61P 3/10 (2006.01); A61P 5/14 (2006.01); A61P 5/16 (2006.01); A61P 5/30 (2006.01); A61P 5/32 (2006.01); A61P 7/00 (2006.01); A61P 7/04 (2006.01); A61P 9/00 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 11/02 (2006.01); A61P 11/06 (2006.01); A61P 15/00 (2006.01); A61P 15/08 (2006.01); A61P 15/18 (2006.01); A61P 17/00 (2006.01); A61P 17/04 (2006.01); A61P 17/06 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); A61P 19/04 (2006.01); A61P 19/10 (2006.01); A61P 21/04 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); A61P 27/14 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 31/04 (2006.01); A61P 31/18 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); A61P 37/02 (2006.01); A61P 37/06 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07J 31/00 (2006.01)
CPC (source: EP US)
A61K 31/37 (2013.01 - EP US); A61K 31/565 (2013.01 - EP US); A61P 1/00 (2017.12 - EP); A61P 1/02 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 1/14 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 5/14 (2017.12 - EP); A61P 5/16 (2017.12 - EP); A61P 5/30 (2017.12 - EP); A61P 5/32 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 7/04 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/02 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 15/08 (2017.12 - EP); A61P 15/18 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/04 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 19/04 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 21/04 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 27/14 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/04 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
EP 2202240 A1 20100630; AT E428720 T1 20090515; AU 7862901 A 20020304; AU 7863101 A 20020304; AU 7863801 A 20020304; CY 1109130 T1 20140702; DE 60138390 D1 20090528; DK 1311532 T3 20090622; EP 1311532 A1 20030521; EP 1311532 B1 20090415; EP 1311533 A1 20030521; EP 1311534 A1 20030521; ES 2323630 T3 20090722; GB 0020498 D0 20001011; JP 2004506741 A 20040304; JP 2004506742 A 20040304; JP 2004511441 A 20040415; JP 4958377 B2 20120620; JP 5074655 B2 20121114; JP 5191079 B2 20130424; PT 1311532 E 20090601; US 2003203855 A1 20031030; US 2003225051 A1 20031204; US 2006281719 A1 20061214; US 7067503 B2 20060627; US 7119081 B2 20061010; US 8030296 B2 20111004; WO 0216392 A1 20020228; WO 0216393 A1 20020228; WO 0216394 A1 20020228
DOCDB simple family (application)
EP 09002167 A 20010817; AT 01956710 T 20010817; AU 7862901 A 20010817; AU 7863101 A 20010817; AU 7863801 A 20010817; CY 091100609 T 20090609; DE 60138390 T 20010817; DK 01956710 T 20010817; EP 01956710 A 20010817; EP 01956712 A 20010817; EP 01956719 A 20010817; ES 01956710 T 20010817; GB 0020498 A 20000818; GB 0103688 W 20010817; GB 0103692 W 20010817; GB 0103705 W 20010817; JP 2002521488 A 20010817; JP 2002521489 A 20010817; JP 2002521490 A 20010817; PT 01956710 T 20010817; US 36711403 A 20030214; US 36762203 A 20030214; US 36836706 A 20060303