EP 1311543 A1 20030521 - T CELL RECEPTOR V BETA-D BETA-J BETA SEQUENCE AND METHODS FOR ITS DETECTION
Title (en)
T CELL RECEPTOR V BETA-D BETA-J BETA SEQUENCE AND METHODS FOR ITS DETECTION
Title (de)
SEQUENZ DES VBETA-DBETA-JBETA-T-ZELLREZEPTORS UND VERFAHREN ZU DESSEN DETEKTION
Title (fr)
SEQUENCE DE RECEPTEURS DES LYMPHOCYTES T V BETA-D BETA-J BETA ET PROCEDES POUR LA DETECTER
Publication
Application
Priority
US 0022988 W 20000822
Abstract (en)
[origin: WO0216434A1] In one embodiment, the present invention is directed to a first oligonucleotide comprising the sequence of or derived from 5'-CTAGGGCGGGCGGGACTCACCTAC-3' or the nucleic acid sequence complementary thereto. The first oligonucleotide can be used with a nucleic acid of between 15 and 30 nucleotides that does not comprise the sequence of the first oligonucleotide and is found in the region from V beta to J beta of the V beta 13.1 gene in V beta 13.1 T cells, wherein the sequences of the oligonucleotide and the nucleic acid are not found on the same strand of the V beta 13.1 gene pair, to amplify a portion of the V beta 13.1 gene. Alternatively, the first oligonucleotide can be used with a labeling moiety in methods of detecting a LGRAGLTY motif found in T cell receptors of V beta 13.1 T cells. This motif is associated with autoimmune diseases, such as multiple sclerosis (MS). Once the motif is detected, the autoimmune disease can be treated or its progress monitored. The autoimmune disease can be treated by administering one ore more peptides comprising the LGRAGLTY motif.
IPC 1-7
IPC 8 full level
A61P 1/04 (2006.01); A61P 3/10 (2006.01); A61K 38/00 (2006.01); A61P 5/14 (2006.01); A61P 19/02 (2006.01); A61P 21/00 (2006.01); A61P 21/04 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07K 14/725 (2006.01)
CPC (source: EP KR)
A61P 1/04 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 5/14 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 21/00 (2018.01 - EP); A61P 21/04 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 27/02 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 14/47 (2013.01 - KR); C07K 14/7051 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0216434 A1 20020228; WO 0216434 A9 20031009; AU 6923900 A 20020304; BR 0017319 A 20040113; CA 2420283 A1 20020228; CN 1505640 A 20040616; EP 1311543 A1 20030521; HU P0400499 A2 20040628; IL 154544 A0 20030917; IL 154544 A 20100531; JP 2004506743 A 20040304; KR 20030086983 A 20031112; MX PA03001569 A 20041213; PL 364914 A1 20041227
DOCDB simple family (application)
US 0022988 W 20000822; AU 6923900 A 20000822; BR 0017319 A 20000822; CA 2420283 A 20000822; CN 00819972 A 20000822; EP 00957650 A 20000822; HU P0400499 A 20000822; IL 15454400 A 20000822; IL 15454403 A 20030219; JP 2002521529 A 20000822; KR 20037002550 A 20030221; MX PA03001569 A 20000822; PL 36491400 A 20000822