EP 1313701 A1 20030528 - PHENOXYBENZYLAMINE DERIVATIVES AS SELECTIVE SEROTONIN RE-UPTAKE INHIBITORS
Title (en)
PHENOXYBENZYLAMINE DERIVATIVES AS SELECTIVE SEROTONIN RE-UPTAKE INHIBITORS
Title (de)
PHENOXYBENZYLAMINDERIVATE ALS SELEKTIVE SEROTONIN-REUPTAKE-INHIBITOREN
Title (fr)
DERIVES DE LA PHENOXYBENZYLAMINE INHIBITEURS SELECTIFS DU RECAPTAGE DE LA SEROTONINE
Publication
Application
Priority
- GB 0021593 A 20000831
- GB 0107116 A 20010321
- IB 0101521 W 20010822
Abstract (en)
[origin: WO0218333A1] A compound of general formula (I) wherein R<1> and R<2> are H, C1-C6alkyl or (CH2)d(C3-C6cycloalkyl) wherein d = 0, 1, 2 or 3; or R<1> and R<2> together with the nitrogen to which they are attached from an azetidine ring; Z or Y is -SR<3> and the other Z or Y is halogen or -R<3>; wherein R<3> is C1-C4 alkyl optionally substituted with fluorine; except that R<3> is not CF3; or Z and Y are linked so that, together with the interconnecting atoms, Z and Y form a fused 5 to 7-membered carbocyclic or heterocyclic ring, and wherein when Z and Y form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; R<4> and R<5>, which may be the same or different, are: A-X, wherein A = -CH=CH- or -(CH2)p- where p is 0, 1 or 2; X is hydrogen, F, CI, Br, I, CONR<6>R<7>, SO2NR<6>R<7>, SO2NHC(=O)R<6>, OH, C1-4alkoxy, NR<8>SO2R<9>, NO2, NR<6>R<11>, CN, CO2R<10>, CHO, SR<10>, S(O)R<9> or SO2R<10>; or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R<13>; wherein R<13> is hydroxy, C1-C4alkoxy, F, C1-C6alkyl, haloalkyl, haloalkoxy, -NH2, NH(C1-C6alkyl) or -N(C1-C6alkyl)2. The compounds of general formula (I) inhibit monoamine reuptake and in particular exhibit activity as selective serotonin reuptake inhibitors.
IPC 1-7
C07C 323/20; C07D 333/54; C07D 327/06; C07D 307/87; C07D 333/72; C07C 311/37; C07D 215/18; C07D 239/74; C07D 277/62; A61K 31/18; A61K 31/38; A61K 31/39; A61K 31/34; A61K 31/135; A61K 31/47
IPC 8 full level
A61K 31/135 (2006.01); A61K 31/137 (2006.01); A61K 31/166 (2006.01); A61K 31/18 (2006.01); A61K 31/192 (2006.01); A61K 31/24 (2006.01); A61K 31/275 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/39 (2006.01); A61K 31/428 (2006.01); A61K 31/47 (2006.01); A61K 31/517 (2006.01); A61P 15/00 (2006.01); A61P 15/10 (2006.01); A61P 25/00 (2006.01); A61P 25/24 (2006.01); A61P 25/30 (2006.01); A61P 43/00 (2006.01); C07C 303/38 (2006.01); C07C 311/08 (2006.01); C07C 311/37 (2006.01); C07C 319/20 (2006.01); C07C 323/20 (2006.01); C07D 215/20 (2006.01); C07D 239/74 (2006.01); C07D 277/62 (2006.01); C07D 307/87 (2006.01); C07D 327/06 (2006.01); C07D 333/54 (2006.01); C07D 333/72 (2006.01)
IPC 8 main group level
CPC (source: EP KR)
A61K 31/135 (2013.01 - EP); A61K 31/343 (2013.01 - EP); A61K 31/381 (2013.01 - EP); A61K 31/39 (2013.01 - EP); A61K 31/47 (2013.01 - EP); A61P 15/00 (2018.01 - EP); A61P 15/10 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/24 (2018.01 - EP); A61P 25/30 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07C 311/08 (2013.01 - EP); C07C 311/37 (2013.01 - KR); C07C 323/20 (2013.01 - EP); C07D 215/20 (2013.01 - EP); C07D 239/74 (2013.01 - EP); C07D 277/62 (2013.01 - EP); C07D 307/87 (2013.01 - EP); C07D 327/06 (2013.01 - EP); C07D 333/54 (2013.01 - EP); C07D 333/72 (2013.01 - EP); C07C 2602/08 (2017.05 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0218333 A1 20020307; AP 2001002265 A0 20010930; AR 031867 A1 20031008; AU 7865001 A 20020313; BG 107544 A 20031031; BR 0113610 A 20030624; CA 2420969 A1 20020307; CN 1449380 A 20031015; CZ 2003467 A3 20040414; DO P2001000242 A 20020515; DZ 3414 A1 20020307; EA 200300206 A1 20030626; EE 200300084 A 20050215; EP 1313701 A1 20030528; HN 2001000191 A 20020311; HR P20030141 A2 20030430; HU P0303385 A2 20040301; IL 154343 A0 20030917; IS 6704 A 20030130; JP 2004507523 A 20040311; KR 20030029889 A 20030416; MA 26945 A1 20041220; MX PA03001848 A 20030604; NO 20030842 D0 20030224; NO 20030842 L 20030428; NZ 523951 A 20040924; OA 12372 A 20060417; PA 8526701 A1 20030728; PE 20020346 A1 20020508; PL 360743 A1 20040920; SK 2012003 A3 20040608; TN SN01131 A1 20051110; UY 26924 A1 20020322
DOCDB simple family (application)
IB 0101521 W 20010822; AP 2001002265 A 20010822; AR P010104114 A 20010829; AU 7865001 A 20010822; BG 10754403 A 20030207; BR 0113610 A 20010822; CA 2420969 A 20010822; CN 01814846 A 20010822; CZ 2003467 A 20010822; DO 2001000242 A 20010829; DZ 013414 A 20010822; EA 200300206 A 20010822; EE P200300084 A 20010822; EP 01956734 A 20010822; HN 2001000191 A 20010828; HR P20030141 A 20030226; HU P0303385 A 20010822; IL 15434301 A 20010822; IS 6704 A 20030130; JP 2002523451 A 20010822; KR 20037003011 A 20030228; MA 27049 A 20030221; MX PA03001848 A 20010822; NO 20030842 A 20030224; NZ 52395101 A 20010822; OA 1200300056 A 20010822; PA 8526701 A 20010824; PE 2001000862 A 20010828; PL 36074301 A 20010822; SK 2012003 A 20010822; TN SN01131 A 20010830; UY 26924 A 20010831