EP 1313710 A1 20030528 - PYRAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS
Title (en)
PYRAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS
Title (de)
PYRAZOLDERIVATE UND IHRE VERWENDUNG ALS PROTEINKINASE INHIBITOREN
Title (fr)
DERIVES PYRAZOLE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DES PROTEINES KINASES
Publication
Application
Priority
- IB 0101540 W 20010824
- US 22941500 P 20000831
Abstract (en)
[origin: WO0218346A1] The invention provides compounds of formula (1) wherein R<1>, R<2>, R<3>, and R<4> are as defined, and their pharmaceutically acceptable salts. Compounds of formula (1) are indicated to have activity inhibiting cdk2, and GSK-3. Pharmaceutical compositions and methods comprising compounds of formula (1) for treating and preventing diseases and conditions comprising abnormal cell growth, such as cancer, and neurodegenerative diseases and conditions and those affected by dopamine neurotransmission. Also described are pharmaceutical compositions and methods comprising compounds of formula (1) for treating male fertility and sperm motility; diabetes mellitus; impaired glucose tolerance; metabolic syndrome or syndrome X; polycystic ovary syndrome; adipogenesis and obesity; myogenesis and frailty, for example age-related decline in physical performance; acute sarcopenia, for example muscle atrophy and/or cachexia associated with burns, bed rest, limb immobilization, or major thoracic, abdominal, and/or orthopedic surgery; sepsis; hair loss, hair thinning, and balding; and immunodeficiency.
IPC 1-7
C07D 231/40; C07D 231/38; C07D 405/04; C07D 401/12; C07D 403/12; C07D 417/06; C07D 413/08; A61K 31/415; A61P 25/00
IPC 8 full level
A61K 31/15 (2006.01); A61K 31/415 (2006.01); A61K 31/4155 (2006.01); A61K 31/428 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/497 (2006.01); A61K 45/00 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 15/08 (2006.01); A61P 15/10 (2006.01); A61P 17/14 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); A61P 31/04 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); A61P 43/00 (2006.01); C07D 231/38 (2006.01); C07D 231/40 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/04 (2006.01); C07D 413/08 (2006.01); C07D 417/06 (2006.01); C07D 417/12 (2006.01)
IPC 8 main group level
CPC (source: EP KR)
A61P 3/00 (2018.01 - EP); A61P 3/04 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 15/08 (2018.01 - EP); A61P 15/10 (2018.01 - EP); A61P 17/14 (2018.01 - EP); A61P 21/00 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/04 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 231/38 (2013.01 - EP); C07D 231/40 (2013.01 - EP KR); C07D 401/12 (2013.01 - EP); C07D 403/12 (2013.01 - EP); C07D 405/04 (2013.01 - EP); C07D 413/08 (2013.01 - EP); C07D 417/06 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0218346 A1 20020307; AP 2001002266 A0 20010930; AR 035345 A1 20040512; AU 8000901 A 20020313; BG 107455 A 20030930; BR 0113574 A 20030722; CA 2420363 A1 20020307; CN 1518543 A 20040804; CR 6881 A 20040311; CZ 2003468 A3 20040512; DO P2001000243 A 20021015; DZ 3398 A1 20020307; EA 200300205 A1 20030626; EC SP034480 A 20030331; EE 200300085 A 20041215; EP 1313710 A1 20030528; GT 200100179 A 20020422; HN 2001000192 A 20010828; HR P20030140 A2 20030430; HU P0302669 A2 20031229; HU P0302669 A3 20040329; IL 154016 A0 20030731; IS 6687 A 20030116; JP 2004507526 A 20040311; KR 20030027093 A 20030403; MA 26946 A1 20041220; MX PA03001785 A 20030604; NO 20030958 D0 20030228; NO 20030958 L 20030228; NZ 523656 A 20041126; OA 12368 A 20040413; PA 8528101 A1 20020730; PE 20020470 A1 20020618; PL 360742 A1 20040920; SK 2002003 A3 20040406; SV 2002000618 A 20021024; TN SN01132 A1 20051110; UY 26909 A1 20020322; YU 14703 A 20060525; ZA 200301064 B 20040419
DOCDB simple family (application)
IB 0101540 W 20010824; AP 2001002266 A 20010824; AR P010104115 A 20010829; AU 8000901 A 20010824; BG 10745503 A 20030113; BR 0113574 A 20010824; CA 2420363 A 20010824; CN 01814761 A 20010824; CR 6881 A 20030115; CZ 2003468 A 20010824; DO 2001000243 A 20010829; DZ 013398 A 20010824; EA 200300205 A 20010824; EC SP034480 A 20030217; EE P200300085 A 20010824; EP 01958287 A 20010824; GT 200100179 A 20010830; HN 2001000192 A 20010828; HR P20030140 A 20030226; HU P0302669 A 20010824; IL 15401601 A 20010824; IS 6687 A 20030116; JP 2002523464 A 20010824; KR 20037002894 A 20030227; MA 27050 A 20030221; MX PA03001785 A 20010824; NO 20030958 A 20030228; NZ 52365601 A 20010824; OA 1200300050 A 20010824; PA 8528101 A 20010831; PE 2001000872 A 20010829; PL 36074201 A 20010824; SK 2002003 A 20010824; SV 2001000618 A 20010830; TN SN01132 A 20010830; UY 26909 A 20010827; YU P14703 A 20010824; ZA 200301064 A 20030207