EP 1313742 A1 20030528 - PROCESS FOR PREPARATION OF HYDRATES OF OLANZAPINE AND THEIR CONVERSION INTO CRYSTALLINE FORMS OF OLANZAPINE
Title (en)
PROCESS FOR PREPARATION OF HYDRATES OF OLANZAPINE AND THEIR CONVERSION INTO CRYSTALLINE FORMS OF OLANZAPINE
Title (de)
VERFAHREN ZUR HERSTELLUNG VON OLANZAPINE-HYDRATEN UND DEREN UMSETZUNGEN IN KRYSTALLINISCHEN FORMEN DER OLANZAPINE
Title (fr)
PROCEDE DE PREPARATION D'HYDRATES D'OLANZAPINE ET DE CONVERSION DE CEUX-CI EN FORMES CRISTALLINES D'OLANZAPINE
Publication
Application
Priority
- IN 709CH2000 A 20000831
- IN 711CH2000 A 20000831
- US 0107258 W 20010307
Abstract (en)
[origin: WO0218390A1] The present invention relates to a method for the preparation of hydrates of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b] [1,5] benzodiazepine (hereinafter referred to as Olanzapine). The present invention also relates to a process for conversion of these hydrates into a pure crystalline form of olanzapine referred to as form-I. The present invention also relates to a method of converting Olanzapine Form-2 to Form-1.
IPC 1-7
IPC 8 full level
A61K 31/551 (2006.01); A61P 25/00 (2006.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); C07D 495/04 (2006.01)
CPC (source: EP)
A61P 25/00 (2018.01); A61P 25/18 (2018.01); A61P 25/22 (2018.01); C07D 495/04 (2013.01)
Citation (third parties)
Third party :
- EP 0454436 B1 19950913 - LILLY INDUSTRIES LTD [GB]
- FIESER L.F.: "ORGANIC EXPERIMENTS", part 7 1964, D.C. HEATH AND COMPANY, BOSTON, article "Crystallization", pages: 41 - 51, XP002970931
- BREWSTER R.Q.; VANDERWERF C.A.; MCEWEN W.E.: "Initized Experiments in Organic Chemistry", vol. 2, June 1965, D. VAN NOSTRAND COMPANY, INC., TORONTO, article "EXPERIMENT 4 - Chrystallization", pages: 18 - 23, XP002970932
- See also references of WO 0218390A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0218390 A1 20020307; AU 4347501 A 20020313; BR 0114031 A 20030909; CA 2420987 A1 20020307; CZ 2003566 A3 20040114; EP 1313742 A1 20030528; HU P0300875 A2 20031229; HU P0300875 A3 20050928; IL 154688 A0 20030917; JP 2004507548 A 20040311; NO 20030926 D0 20030227; NO 20030926 L 20030424; RU 2003108745 A 20050110; SK 2502003 A3 20040302
DOCDB simple family (application)
US 0107258 W 20010307; AU 4347501 A 20010307; BR 0114031 A 20010307; CA 2420987 A 20010307; CZ 2003566 A 20010307; EP 01916449 A 20010307; HU P0300875 A 20010307; IL 15468801 A 20010307; JP 2002523905 A 20010307; NO 20030926 A 20030227; RU 2003108745 A 20010307; SK 2502003 A 20010307