EP 1315476 A2 20030604 - NITRIC OXIDE-PRODUCING HYDROGEL MATERIALS
Title (en)
NITRIC OXIDE-PRODUCING HYDROGEL MATERIALS
Title (de)
STICKSTOFFMONOXID-FORMENDE HYDROGEL-MATERIALIEN
Title (fr)
MATERIAUX HYDROGELS PRODUISANT DU MONOXYDE D'AZOTE
Publication
Application
Priority
- US 0127414 W 20010904
- US 65340600 A 20000901
Abstract (en)
[origin: WO0217880A2] Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The polymeric materials can be formed into films, coatings, or microparticles for application to medical devices, such as stents, vascular grafts and catheters. The polymeric materials can also be applied directly to biological tissues and can be polymerized in situ. The hydrogels are formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed. The macromers can form a homo or hetero-dispersion or solution, which is polymerized to form a hydrogel material, that in the latter case can be a semi-interpenetrating network or interpenetrating network. Compounds to be released can be physically entrapped, covalently or ionically bound to macromer, or actually form a part of the polymeric material. The hydrogel can be formed by ionic and/or covalent crosslinking. Other active agents, including therapeutic, prophylactic, or diagnostic agents, can also be included within the polymeric material.
IPC 1-7
IPC 8 full level
A61K 45/00 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 11/06 (2006.01); A61P 15/10 (2006.01); A61P 17/02 (2006.01); A61P 19/02 (2006.01); C08F 299/02 (2006.01); C08G 65/333 (2006.01); C08G 65/334 (2006.01)
CPC (source: EP)
A61K 47/58 (2017.07); A61K 47/60 (2017.07); A61K 47/6903 (2017.07); A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 11/06 (2017.12); A61P 15/10 (2017.12); A61P 17/02 (2017.12); A61P 19/02 (2017.12)
Citation (search report)
See references of WO 0217880A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0217880 A2 20020307; WO 0217880 A3 20030327; AU 8869401 A 20020313; EP 1315476 A2 20030604; JP 2002155137 A 20020528; JP 4841066 B2 20111221
DOCDB simple family (application)
US 0127414 W 20010904; AU 8869401 A 20010904; EP 01968448 A 20010904; JP 2001188905 A 20010521