Global Patent Index - EP 1315476 A2

EP 1315476 A2 2003-06-04 - NITRIC OXIDE-PRODUCING HYDROGEL MATERIALS

Title (en)

NITRIC OXIDE-PRODUCING HYDROGEL MATERIALS

Title (de)

STICKSTOFFMONOXID-FORMENDE HYDROGEL-MATERIALIEN

Title (fr)

MATERIAUX HYDROGELS PRODUISANT DU MONOXYDE D'AZOTE

Publication

EP 1315476 A2 (EN)

Application

EP 01968448 A

Priority

  • US 0127414 W
  • US 65340600 A

Abstract (en)

[origin: WO0217880A2] Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The polymeric materials can be formed into films, coatings, or microparticles for application to medical devices, such as stents, vascular grafts and catheters. The polymeric materials can also be applied directly to biological tissues and can be polymerized in situ. The hydrogels are formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed. The macromers can form a homo or hetero-dispersion or solution, which is polymerized to form a hydrogel material, that in the latter case can be a semi-interpenetrating network or interpenetrating network. Compounds to be released can be physically entrapped, covalently or ionically bound to macromer, or actually form a part of the polymeric material. The hydrogel can be formed by ionic and/or covalent crosslinking. Other active agents, including therapeutic, prophylactic, or diagnostic agents, can also be included within the polymeric material.

IPC 1-7 (main, further and additional classification)

A61K 9/00

IPC 8 full level (invention and additional information)

A61K 45/00 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 11/06 (2006.01); A61P 15/10 (2006.01); A61P 17/02 (2006.01); A61P 19/02 (2006.01); C08F 299/02 (2006.01); C08G 65/333 (2006.01); C08G 65/334 (2006.01)

CPC (invention and additional information)

A61K 47/6903 (2017.08); A61K 47/58 (2017.08); A61K 47/60 (2017.08)

Citation (search report)

See references of WO 0217880A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0217880 A2 20020307; WO 0217880 A3 20030327; AU 8869401 A 20020313; EP 1315476 A2 20030604; JP 2002155137 A 20020528; JP 4841066 B2 20111221

INPADOC legal status


2005-01-05 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20040702

2004-01-07 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031121

2003-08-20 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: HILL-WEST, JENNIFER, L.

2003-08-20 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: MASTERS, KRISTYN, SIMCHA

2003-06-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20030401

2003-06-04 [AK] DESIGNATED CONTRACTING STATES:

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2003-06-04 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Countries: AL LT LV MK RO SI