EP 1315726 A1 20030604 - 7- OXO PYRIDOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION
Title (en)
7- OXO PYRIDOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION
Title (de)
7-OXOPYRIDOPYRIMIDINE ALS INHIBITOREN VON ZELLVERMEHRUNG
Title (fr)
7 OXO PYRIDOPYRIMIDINES COMME INHIBITEURS D'UNE PROLIFERATION CELLULAIRE
Publication
Application
Priority
- EP 0109689 W 20010822
- US 22958400 P 20000831
Abstract (en)
[origin: WO0218380A1] Compounds of formula (I) wherein R<1> is hydrogen or alkyl; R2 is substituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl-aryl, heterocyclyl, heterocyclyl spiro cycloalkyl, aralkoxy, alkoxy, -alkylene-S(O)n-alkyl(where n is 1 or 2) or -SO2Ar<2>; R<3> is hydrogen, amino, monoalkylamino, dialkylamino, acylamino, -NR<a>-C(=O)-R<b> (where R<a> is hydrogen or alkyl and R<b> is hetericyclyl or heteroalkyl) alkyl, cycloalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, -alkylene-C(O)-R (where R is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino) acyl, or phthalimidoalkyl; and each of Ar<1> and Ar<2> is independently aryl, and their use for treatment of disorders selected from the group consisting of arthritis, Crohns disease, Alzheimer's disease, irritable bowel syndrome, adult respiratory distress syndrome, and chronic obstructive pulmonary disease.
IPC 1-7
IPC 8 full level
A61K 31/519 (2006.01); A61P 1/04 (2006.01); A61P 11/00 (2006.01); A61P 19/02 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP KR)
A61P 1/04 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 471/04 (2013.01 - EP KR)
Citation (search report)
See references of WO 0218380A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0218380 A1 20020307; AR 033681 A1 20040107; AU 2001293784 B2 20070830; AU 9378401 A 20020313; BR 0113628 A 20030701; CA 2420286 A1 20020307; CN 1275964 C 20060920; CN 1451005 A 20031022; EP 1315726 A1 20030604; GT 200100191 A 20020516; JP 2004507541 A 20040311; JP 4141830 B2 20080827; KR 100571339 B1 20060417; KR 20030022422 A 20030315; MX PA03001821 A 20030604; PA 8527301 A1 20020730; PE 20020406 A1 20020517; UY 26918 A1 20020228; ZA 200301079 B 20040507
DOCDB simple family (application)
EP 0109689 W 20010822; AR P010104132 A 20010830; AU 2001293784 A 20010822; AU 9378401 A 20010822; BR 0113628 A 20010822; CA 2420286 A 20010822; CN 01815030 A 20010822; EP 01974206 A 20010822; GT 200100191 A 20010918; JP 2002523895 A 20010822; KR 20037002936 A 20030227; MX PA03001821 A 20010822; PA 8527301 A 20010828; PE 2001000860 A 20010828; UY 26918 A 20010830; ZA 200301079 A 20030207