Global Patent Index - EP 1315726 A1

EP 1315726 A1 2003-06-04 - 7- OXO PYRIDOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION

Title (en)

7- OXO PYRIDOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION

Title (de)

7-OXOPYRIDOPYRIMIDINE ALS INHIBITOREN VON ZELLVERMEHRUNG

Title (fr)

7 OXO PYRIDOPYRIMIDINES COMME INHIBITEURS D'UNE PROLIFERATION CELLULAIRE

Publication

EP 1315726 A1 (EN)

Application

EP 01974206 A

Priority

  • EP 0109689 W
  • US 22958400 P

Abstract (en)

[origin: WO0218380A1] Compounds of formula (I) wherein R<1> is hydrogen or alkyl; R2 is substituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl-aryl, heterocyclyl, heterocyclyl spiro cycloalkyl, aralkoxy, alkoxy, -alkylene-S(O)n-alkyl(where n is 1 or 2) or -SO2Ar<2>; R<3> is hydrogen, amino, monoalkylamino, dialkylamino, acylamino, -NR<a>-C(=O)-R<b> (where R<a> is hydrogen or alkyl and R<b> is hetericyclyl or heteroalkyl) alkyl, cycloalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, -alkylene-C(O)-R (where R is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino) acyl, or phthalimidoalkyl; and each of Ar<1> and Ar<2> is independently aryl, and their use for treatment of disorders selected from the group consisting of arthritis, Crohns disease, Alzheimer's disease, irritable bowel syndrome, adult respiratory distress syndrome, and chronic obstructive pulmonary disease.

IPC 1-7 (main, further and additional classification)

C07D 471/04; A61K 31/519; A61P 29/00; A61P 31/00

IPC 8 full level (invention and additional information)

A61K 31/519 (2006.01); A61P 1/04 (2006.01); A61P 11/00 (2006.01); A61P 19/02 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01)

CPC (invention and additional information)

C07D 471/04 (2013.01)

Citation (search report)

See references of WO 0218380A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0218380 A1 20020307; AR 033681 A1 20040107; AU 2001293784 B2 20070830; AU 9378401 A 20020313; BR 0113628 A 20030701; CA 2420286 A1 20020307; CN 1275964 C 20060920; CN 1451005 A 20031022; EP 1315726 A1 20030604; GT 200100191 A 20020516; JP 2004507541 A 20040311; JP 4141830 B2 20080827; KR 100571339 B1 20060417; KR 20030022422 A 20030315; MX PA03001821 A 20030604; PA 8527301 A1 20020730; PE 04062002 A1 20020517; UY 26918 A1 20020228; ZA 200301079 B 20040507

INPADOC legal status


2009-11-11 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20090417

2008-11-05 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20081006

2003-06-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20030331

2003-06-04 [AK] DESIGNATED CONTRACTING STATES:

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2003-06-04 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Countries: AL LT LV MK RO SI