EP 1315794 A1 20030604 - GENETIC DEMONSTRATION OF REQUIREMENT FOR NKX6.1, NKX2.2 AND NKX6.2 IN VENTRAL NEURON GENERATION
Title (en)
GENETIC DEMONSTRATION OF REQUIREMENT FOR NKX6.1, NKX2.2 AND NKX6.2 IN VENTRAL NEURON GENERATION
Title (de)
GENETISCHE DEMONSTRATIONDER NOTWENDIGKEIT VON NKX6.1, NKX2.2 UND NKX6.2 ZUR GENERIERUNG VON VENTRALEN NERVENZELLEN
Title (fr)
DEMONSTRATION GENETIQUE DU BESOIN DE NKX6.1, NKX2.2 ET NKX6.2 POUR LA PRODUCTION DE NEURONES VENTRAUX
Publication
Application
Priority
- US 0127256 W 20010831
- US 65446200 A 20000901
Abstract (en)
[origin: WO0218545A1] This invention provides a method of converting a stem cell into a ventral neuron which comprises introducing into the stem cell a nucleic acid which expresses homeodomain transcription factor Nkx6.1 or Nkx6.2 protein in the stem cell so as to thereby convert the stem cell into the ventral neuron. Provided are methods of diagnosing a motor neuron degenerative disease in a subject. Also provides is a method of treating neuronal degeneration in a subjet which comprises implanting in diseased neural tissue of the subject a neural stem cell which is capable of expressing homeodomain Nkx6.1 or Nkx6.2 protein under conditions such that the stem cell is converted into a motor neuron after implantation, thereby treating neuronal degeneration in the subject.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); C12N 5/02 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
C07K 14/4702 (2013.01); A61K 48/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0218545 A1 20020307; AU 8863401 A 20020313; CA 2419851 A1 20020307; EP 1315794 A1 20030604; EP 1315794 A4 20050126
DOCDB simple family (application)
US 0127256 W 20010831; AU 8863401 A 20010831; CA 2419851 A 20010831; EP 01968382 A 20010831