Global Patent Index - EP 1315794 A1

EP 1315794 A1 2003-06-04 - GENETIC DEMONSTRATION OF REQUIREMENT FOR NKX6.1, NKX2.2 AND NKX6.2 IN VENTRAL NEURON GENERATION

Title (en)

GENETIC DEMONSTRATION OF REQUIREMENT FOR NKX6.1, NKX2.2 AND NKX6.2 IN VENTRAL NEURON GENERATION

Title (de)

GENETISCHE DEMONSTRATIONDER NOTWENDIGKEIT VON NKX6.1, NKX2.2 UND NKX6.2 ZUR GENERIERUNG VON VENTRALEN NERVENZELLEN

Title (fr)

DEMONSTRATION GENETIQUE DU BESOIN DE NKX6.1, NKX2.2 ET NKX6.2 POUR LA PRODUCTION DE NEURONES VENTRAUX

Publication

EP 1315794 A1 (EN)

Application

EP 01968382 A

Priority

  • US 0127256 W
  • US 65446200 A

Abstract (en)

[origin: WO0218545A1] This invention provides a method of converting a stem cell into a ventral neuron which comprises introducing into the stem cell a nucleic acid which expresses homeodomain transcription factor Nkx6.1 or Nkx6.2 protein in the stem cell so as to thereby convert the stem cell into the ventral neuron. Provided are methods of diagnosing a motor neuron degenerative disease in a subject. Also provides is a method of treating neuronal degeneration in a subjet which comprises implanting in diseased neural tissue of the subject a neural stem cell which is capable of expressing homeodomain Nkx6.1 or Nkx6.2 protein under conditions such that the stem cell is converted into a motor neuron after implantation, thereby treating neuronal degeneration in the subject.

IPC 1-7 (main, further and additional classification)

C12N 5/00; C12N 5/02; C12N 15/63; C12N 15/85; C12N 15/87

IPC 8 full level (invention and additional information)

C07K 14/47 (2006.01); C12N 5/02 (2006.01); A61K 48/00 (2006.01)

CPC (invention and additional information)

C07K 14/4702 (2013.01); A61K 48/00 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0218545 A1 20020307; AU 8863401 A 20020313; CA 2419851 A1 20020307; EP 1315794 A1 20030604; EP 1315794 A4 20050126

INPADOC legal status


2010-04-21 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20091030

2005-01-26 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20041212

2004-12-22 [RAP1] TRANSFER OF RIGHTS OF AN APPLICATION

- Owner name: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF

2004-12-22 [RAP1] TRANSFER OF RIGHTS OF AN APPLICATION

- Owner name: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

2003-06-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20030328

2003-06-04 [AK] DESIGNATED CONTRACTING STATES:

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2003-06-04 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Countries: AL LT LV MK RO SI