Global Patent Index - EP 1315798 A2

EP 1315798 A2 2003-06-04 - HOST CELLS FOR PACKING A RECOMBINANT ADENO-ASSOCIATED VIRUS (RAAV), METHOD FOR THE PRODUCTION AND USE THEREOF

Title (en)

HOST CELLS FOR PACKING A RECOMBINANT ADENO-ASSOCIATED VIRUS (RAAV), METHOD FOR THE PRODUCTION AND USE THEREOF

Title (de)

WIRTSZELLEN ZUR VERPACKUNG VON REKOMBINANTEM ADENO-ASSOZIIERTEM VIRUS (RAAV), VERFAHREN ZU IHRER HERSTELLUNG UND DEREN VERWENDUNG

Title (fr)

CELLULES HOTES POUR EMPAQUETER UN VIRUS ADENO-ASSOCIE RECOMBINE (RAAV), LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION

Publication

EP 1315798 A2 (DE)

Application

EP 01967320 A

Priority

  • DE 10044384 A
  • EP 0110370 W

Abstract (en)

[origin: WO0220748A2] The invention relates to host cells for packing a recombinant adeno-associated virus (rAAV). Said cells contain at least one copy of a first auxiliary construct for expressing at least one AAV Rep protein, and at least one copy of another auxiliary construct for expressing at least one AAV Cap protein. The invention also relates to auxiliary constructs for expressing at least one AAV Rep protein and one AAV Cap protein in a host cell; vector constructs comprising at least one nucleic acid which is heterologous in relation to the AAV; a method for producing a host cell for packing a recombinant adeno-associated virus (rAAV); and the use of the host cell for producing an rAAV.

[origin: WO0220748A2] Die vorliegende Erfindung betrifft Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), die mindestens eine Kopie eines ersten Helferkonstruktes zur Expression mindestens eines AAV Rep-Proteins und mindestens eine Kopie eines weiteren Helferkonstruktes zur Expression mindestens eines AAV Cap-Proteins enthält. Weiterhin betrifft die Erfindung Helferkonstrukte zur Expression wenigstens eines AAV Rep-proteins und AAV Cap-Proteins in einer Wirtszelle, Vektorkonstrukte, welche ein oder mehrere zu AAV heterologe Nukleinsäuren aufweisen sowie Verfahren zur Herstellung einer Wirtszelle zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV) und die Verwendung der Wirtszelle zur Herstellung von rAAV.

IPC 1-7 (main, further and additional classification)

C12N 5/10; C12N 15/86

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C07K 14/015 (2006.01); C12N 5/10 (2006.01); C12N 15/864 (2006.01); A61K 48/00 (2006.01)

CPC (invention and additional information)

C12N 7/00 (2013.01); C07K 14/005 (2013.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14152 (2013.01)

Citation (search report)

See references of WO 0220748A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0220748 A2 20020314; WO 0220748 A3 20030320; WO 0220748 A8 20040304; AU 8772001 A 20020322; CA 2421442 A1 20030306; DE 10044384 A1 20020418; DE 10066104 A1 20030109; EP 1315798 A2 20030604; JP 2004508041 A 20040318; US 2004087026 A1 20040506

INPADOC legal status


2006-10-25 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20060401

2003-06-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20030326

2003-06-04 [AK] DESIGNATED CONTRACTING STATES:

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR