Global Patent Index - EP 1315804 A2

EP 1315804 A2 2003-06-04 - NOVEL MMP-2 DERIVATIVES FOR USE AS INHIBITORS OF INTEGRIN ALPHA VBETA 3

Title (en)

NOVEL MMP-2 DERIVATIVES FOR USE AS INHIBITORS OF INTEGRIN ALPHA VBETA 3

Title (de)

NEUE MMP-2-DERIVATE ALS INHIBITOREN DES INTEGRINS ALPHA V BETA 3

Title (fr)

NOUVEAUX DERIVES DE MMP2 UTILISES COMME INHIBITEURS DE L'INTEGRINE ALPHA VBETA 3?

Publication

EP 1315804 A2 (DE)

Application

EP 01980289 A

Priority

  • DE 10044325 A
  • EP 0109899 W

Abstract (en)

[origin: WO0220566A2] The invention relates to novel compounds of the formula (I), which are biologically active as the ligands of integrin alpha V beta 3 and wherein X represents H, an acyl or a peptide fragment of 1 to 20 amino acids, selected from the list of the naturally occurring amino acids, Y represents a peptide fragment selected from the sequence range 466-660 of human Pro-MMP-2, Z represents OH, NH2, NHA, NA2 or a peptide fragment of 1 to 20 amino acids, selected from the list of the naturally occurring amino acids, A represents an alkyl having 1-10 C atoms, and acyl represents an alkanoyl having 1-10 C atoms, wherein the primary amino groups can be also provided with conventional amine protecting groups. The invention further relates to the physiologically acceptable salts and solvates of these novel compounds.

IPC 1-7 (main, further and additional classification)

C12N 9/64; A61K 38/48

IPC 8 full level (invention and additional information)

C12N 9/50 (2006.01); A61K 38/55 (2006.01); A61P 1/04 (2006.01); A61P 3/10 (2006.01); A61P 3/14 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 9/14 (2006.01); A61P 11/00 (2006.01); A61P 13/10 (2006.01); A61P 13/12 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 27/06 (2006.01); A61P 27/10 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 31/04 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C12N 9/64 (2006.01)

CPC (invention and additional information)

C12N 9/6491 (2013.01)

Citation (search report)

See references of WO 0220566A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0220566 A2 20020314; WO 0220566 A3 20020627; AU 1217202 A 20020322; CA 2421283 A1 20030305; DE 10044325 A1 20020321; EP 1315804 A2 20030604; JP 2004510710 A 20040408

INPADOC legal status


2004-08-25 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040217

2003-08-27 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030710

2003-06-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20030131

2003-06-04 [AK] DESIGNATED CONTRACTING STATES:

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2003-06-04 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Countries: AL LT LV MK RO SI