EP 1315838 A2 20030604 - METHOD OF ESTABLISHING RESISTANCE PROFILES OF TISSUES AND CELL LINES
Title (en)
METHOD OF ESTABLISHING RESISTANCE PROFILES OF TISSUES AND CELL LINES
Title (de)
VERFAHREN ZUR ERFASSUNG VON RESISTENZ-PROFILEN VON GEWEBEN UND ZELLLINIEN
Title (fr)
PROCEDE DE RELEVE DE PROFILS DE RESISTANCE DE TISSUS ET DE LIGNEES CELLULAIRES
Publication
Application
Priority
- DE 0103323 W 20010903
- DE 10043591 A 20000901
Abstract (en)
[origin: WO0218630A2] The efficiency of the chemotherapy of malign diseases is limited by resistances vis-à-vis the cytostatics used, which resistances are mediated by a plurality of different mechanisms that proceed at the same time or sequentially. The invention relates to the use of a method of establishing resistance profiles using RNA from tissues or cell lines by way of real-time RT PCR technology (carried out, for example, on the "Light Cycler" of Roche Diagnostics GmbH). The invention allows a quantitative analysis of the expressions of different genes that are associated with the development or the intensification or the reduction of resistances. Based thereon it is, for example, possible to establish individual patient resistance profiles that form the molecular-biological base for the selection of appropriate cytostatics before and also during the particular tumor chemotherapy. The inventive method also allows a prognosis of the chances of success (response) of certain chemotherapeutical regimes.
IPC 1-7
IPC 8 full level
C12Q 1/68 (2006.01); C12Q 1/6886 (2018.01)
CPC (source: EP US)
C12Q 1/6886 (2013.01 - EP US); C12Q 2600/106 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US); C12Q 2600/16 (2013.01 - EP US)
Citation (search report)
See references of WO 0218630A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0218630 A2 20020307; WO 0218630 A3 20021121; DE 10043591 A1 20020314; EP 1315838 A2 20030604; US 2004058352 A1 20040325
DOCDB simple family (application)
DE 0103323 W 20010903; DE 10043591 A 20000901; EP 01980157 A 20010903; US 41549103 A 20030430