EP 1317265 A2 20030611 - METHOD FOR DIAGNOSING NEURONAL DISEASES AND FOR TREATING PRIMARY HEMOSTASIS DEFICIENCY

Title (en)

METHOD FOR DIAGNOSING NEURONAL DISEASES AND FOR TREATING PRIMARY HEMOSTASIS DEFICIENCY

Title (de)

VERFAHREN ZUR DIAGNOSTIK VON NEURONALEN ERKRANKUNGEN SOWIE ZUR BEHANDLUNG DER DEFIZIENTEN PRIMÄREN HÄMOSTASE

Title (fr)

PROCEDE POUR DIAGNOSTIQUER DES MALADIES NEURONALES ET POUR TRAITER L'HEMOSTASE PRIMAIRE DEFICIENTE

Publication

EP 1317265 A2 20030611 (DE)

Application

EP 01971618 A 20010827

Priority

DE 0103178 W 20010827
DE 10043124 A 20000831

Abstract (en)

[origin: WO0217891A2] The invention relates to a method for diagnosing neuronal diseases and for treating primary hemostasis deficiency. The invention further relates to a method for suppressing the immune system, which is inter alia significant for transplantation medicine and for the treatment of allergies. The invention is used in the field of medicine and in the pharmaceutical industry. The invention is worked according to the claims. The invention is based on the discovery that serotonin is synthesized by TPH isoenzymes that are differently expressed in the neurons in the peripheral tissues. Gene targeting was used to show that an isoform, the peripheral enzyme (referred to in the following as TPH), is responsible for maintaining primary hemostasis and T-cell mediated immune responses. Another isoform, the newly identified neuron-specific TPH (referred to as nTPH) synthesizes serotonin irrespective thereof in the central nervous system. The invention further relates to the newly identified neuronal tryptophane hydroxylase (nTPH) that differs from the TPH known so far in the regulatory domain.

IPC 1-7

A61K 31/405; A61P 37/00; A61K 45/06

IPC 8 full level

A61K 45/00 (2006.01); A61K 31/00 (2006.01); A61K 31/198 (2006.01); A61K 31/4045 (2006.01); A61K 31/405 (2006.01); A61K 31/4353 (2006.01); A61K 31/436 (2006.01); A61K 31/7105 (2006.01); A61K 38/13 (2006.01); A61K 45/06 (2006.01); A61K 48/00 (2006.01); A61K 49/00 (2006.01); A61P 3/10 (2006.01); A61P 7/02 (2006.01); A61P 7/04 (2006.01); A61P 9/10 (2006.01); A61P 37/00 (2006.01); A61P 37/02 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP US)

A61K 31/00 (2013.01 - EP US); A61K 31/4353 (2013.01 - EP US); A61K 31/436 (2013.01 - EP US); A61K 38/13 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61K 49/0004 (2013.01 - EP US); A61P 3/10 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 7/04 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP)

C-Set (source: EP US)

Citation (search report)

See references of WO 0217891A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0217891 A2 20020307; WO 0217891 A3 20021017; DE 10043124 A1 20020314; EP 1317265 A2 20030611; JP 2004507491 A 20040311; US 2004014656 A1 20040122; US 7049336 B2 20060523

DOCDB simple family (application)

DE 0103178 W 20010827; DE 10043124 A 20000831; EP 01971618 A 20010827; JP 2002522865 A 20010827; US 36347403 A 20030722