Global Patent Index - EP 1317288 A2

EP 1317288 A2 2003-06-11 - METHOD AND COMPOSITION FOR TREATING TUMORS BY SELECTIVE INDUCTION OF APOPTOSIS

Title (en)

METHOD AND COMPOSITION FOR TREATING TUMORS BY SELECTIVE INDUCTION OF APOPTOSIS

Title (de)

VERFAHREN UND ZUSAMMENSETZUNG ZUR BEHANDLUNG VON TUMOREN DURCH SELEKTIVE INDUKTION VON APOPTOSE

Title (fr)

METHODE ET COMPOSITION DE TRAITEMENT DES TUMEURS PAR INDUCTION SELECTIVE DE L'APOPTOSE

Publication

EP 1317288 A2 (EN)

Application

EP 01970744 A

Priority

  • US 0128259 W
  • US 65877900 A

Abstract (en)

[origin: WO0222175A2] Compositions and methods are provided for inducing death of cancer cells through apotposis mediated by the death ligand, TRAIL. The method comprising: introducing an expression vector into a group of cells comprising cells that express a receptor for TRAIL. The expression vector comprises a polynucleotide sequence encoding TRAIL whose expression is preferably regulated by a conditional promoter in the vector. The cells into which the expression vector is introduced express TRAIL when conditions are suitable to activate the conditional promoter. The expressed TRAIL induces cell death in those cells which express the TRAIL receptor through interaction between TRAIL and the receptor such as DR4 and DR5. The method can be used for treating tumors site-specifically and in a dose-adjustable manner.

IPC 1-7 (main, further and additional classification)

A61K 48/00; A61P 35/00

IPC 8 full level (invention and additional information)

A61K 9/127 (2006.01); A61K 31/56 (2006.01); A61K 31/568 (2006.01); A61K 31/57 (2006.01); A61K 31/573 (2006.01); A61K 31/65 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 38/19 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01)

CPC (invention and additional information)

A61K 48/00 (2013.01); A61K 38/191 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 0222175A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0222175 A2 20020321; WO 0222175 A3 20020808; AU 9072001 A 20020326; CA 2421585 A1 20020321; CN 1744919 A 20060308; EP 1317288 A2 20030611; JP 2004526666 A 20040902

INPADOC legal status


2006-11-15 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20060401

2003-06-11 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20030311

2003-06-11 [AK] DESIGNATED CONTRACTING STATES:

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2003-06-11 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Countries: AL LT LV MK RO SI