EP 1317288 A2 20030611 - METHOD AND COMPOSITION FOR TREATING TUMORS BY SELECTIVE INDUCTION OF APOPTOSIS
Title (en)
METHOD AND COMPOSITION FOR TREATING TUMORS BY SELECTIVE INDUCTION OF APOPTOSIS
Title (de)
VERFAHREN UND ZUSAMMENSETZUNG ZUR BEHANDLUNG VON TUMOREN DURCH SELEKTIVE INDUKTION VON APOPTOSE
Title (fr)
METHODE ET COMPOSITION DE TRAITEMENT DES TUMEURS PAR INDUCTION SELECTIVE DE L'APOPTOSE
Publication
Application
Priority
- US 0128259 W 20010910
- US 65877900 A 20000911
Abstract (en)
[origin: WO0222175A2] Compositions and methods are provided for inducing death of cancer cells through apotposis mediated by the death ligand, TRAIL. The method comprising: introducing an expression vector into a group of cells comprising cells that express a receptor for TRAIL. The expression vector comprises a polynucleotide sequence encoding TRAIL whose expression is preferably regulated by a conditional promoter in the vector. The cells into which the expression vector is introduced express TRAIL when conditions are suitable to activate the conditional promoter. The expressed TRAIL induces cell death in those cells which express the TRAIL receptor through interaction between TRAIL and the receptor such as DR4 and DR5. The method can be used for treating tumors site-specifically and in a dose-adjustable manner.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 31/56 (2006.01); A61K 31/568 (2006.01); A61K 31/57 (2006.01); A61K 31/573 (2006.01); A61K 31/65 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 38/19 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 38/191 (2013.01); A61K 48/00 (2013.01); A61P 35/00 (2017.12); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 0222175A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0222175 A2 20020321; WO 0222175 A3 20020808; AU 9072001 A 20020326; CA 2421585 A1 20020321; CN 1744919 A 20060308; EP 1317288 A2 20030611; JP 2004526666 A 20040902
DOCDB simple family (application)
US 0128259 W 20010910; AU 9072001 A 20010910; CA 2421585 A 20010910; CN 01817315 A 20010910; EP 01970744 A 20010910; JP 2002526423 A 20010910