EP 1317481 A2 20030611 - VACCINES FOR EQUINE HERPESVIRUS TYPE-1: VIRUSES HARBORING MUTATIONS WITHIN THE IMMEDIATE EARLY GENE
Title (en)
VACCINES FOR EQUINE HERPESVIRUS TYPE-1: VIRUSES HARBORING MUTATIONS WITHIN THE IMMEDIATE EARLY GENE
Title (de)
IMPFSTOFFE GEGEN PFERDEHERPESVIRUS-1 : VIREN MIT MUTATIONEN INNERHALB DES "IMMEDIATE-EARLY" GENS
Title (fr)
VACCINS POUR LE TYPE 1 DU VIRUS HERPETIQUE EQUIN: MUTATIONS HEBERGEANT LES VIRUS DANS LE GENE PRECOCE IMMEDIAT
Publication
Application
Priority
- US 0123612 W 20010727
- US 62674800 A 20000727
Abstract (en)
[origin: WO0209750A2] This invention relates to mutant Equine herpesvirus type-1 (EHV-1) isolates, and in particular, EHV-1 isolates carrying mutations in the immediate-early (IE) gene of the viral genome. A panel of EHV-1 mutant isolates have been described. Preffered EHV-1 isolates are those which are replication-competent and nonpathogenic. The mutant EHV-1 isolates of the present invention are useful in formulating vaccine compositions for preventing and treating EHV-1 infections in horses. The present invention further provides methods of determining the pathogenicity of an EHV-1 virus present in a horse subject which has been previously immunized with a non-pathogenic EHV-1 isolate of the present invention.
IPC 1-7
IPC 8 full level
A61K 39/245 (2006.01); A61K 39/27 (2006.01); A61P 31/22 (2006.01); C07K 14/03 (2006.01); C07K 14/035 (2006.01); C12N 7/00 (2006.01); C12N 7/04 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); C12Q 1/70 (2006.01); G01N 27/447 (2006.01); G01N 33/483 (2006.01); G01N 33/53 (2006.01); G01N 33/569 (2006.01)
CPC (source: EP)
A61K 39/12 (2013.01); A61K 39/245 (2013.01); A61P 31/22 (2017.12); C07K 14/005 (2013.01); C12N 7/00 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/543 (2013.01); C12N 2710/16722 (2013.01); C12N 2710/16734 (2013.01); C12N 2710/16761 (2013.01)
Citation (search report)
See references of WO 0209750A2
Citation (examination)
- US 5292653 A 19940308 - KIT MALON [US], et al
- LEWIS ET AL: "Transcriptional Control of the Equine Herpesvirus 1 Immediate Early Gene", VIROLOGY, vol. 197, no. 2, 1993, pages 788 - 792
- SUGAHARA ET AL: "Adaptation of equine herpesvirus 1 to unnatural host led to mutation of the gC resulting in increased susceptibility of the virus to heparin", ARCHIVES OF VIROLOGY, vol. 142, no. 9, 1997, pages 1849 - 1856
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0209750 A2 20020207; WO 0209750 A3 20030327; AR 031599 A1 20030924; AU 8299701 A 20020213; CA 2417340 A1 20020207; DE 01961753 T1 20040311; EP 1317481 A2 20030611; JP 2004512826 A 20040430; MX PA03000823 A 20030910; NZ 523772 A 20040625
DOCDB simple family (application)
US 0123612 W 20010727; AR P010103602 A 20010727; AU 8299701 A 20010727; CA 2417340 A 20010727; DE 01961753 T 20010727; EP 01961753 A 20010727; JP 2002515303 A 20010727; MX PA03000823 A 20010727; NZ 52377201 A 20010727