Global Patent Index - EP 1317556 A1

EP 1317556 A1 2003-06-11 - FUSION PROTEIN FROM ANTIBODY CYTOKINE-CYTOKINE INHIBITOR (SELECTOKINE) FOR USE AS TARGET-SPECIFIC PRODRUG

Title (en)

FUSION PROTEIN FROM ANTIBODY CYTOKINE-CYTOKINE INHIBITOR (SELECTOKINE) FOR USE AS TARGET-SPECIFIC PRODRUG

Title (de)

FUSIONSPROTEIN AUS ANTIKÖRPER-ZYTOKIN-ZYTOKIN INHIBITOR (SELEKTOKIN) ALS ZIELSPEZIFISCHES PRODRUG

Title (fr)

PROTEINE DE FUSION CONSTITUEE D'UN INHIBITEUR D'ANTICORPS-CYTOKINE-CYTOKINE (SELECTOKINE) SERVANT DE PROMEDICAMENT SPECIFIQUE A LA CIBLE

Publication

EP 1317556 A1 (DE)

Application

EP 01974261 A

Priority

  • DE 10045592 A
  • EP 0110730 W

Abstract (en)

[origin: WO0222833A1] The invention relates to a polypeptide having preferably antitumoral and/or immunomodulating cytokine properties which can be activated by processing it <i>in vivo</i>. Said polypeptide comprises a central region that has a specific biological activity. At the C-terminus, said region comprises a region with a processing unit and an inhibitor domain while at its N-terminus it comprises a region that selectively recognizes a macromolecule on a cell surface or a component of the extracellular matrix.

[origin: WO0222833A1] Die vorliegende Erfindung betrifft ein Polypeptid mit vorzugsweise antitumoralen und/oder immunmodulierenden Zytokineigenschaften, welches durch Prozessierung <i>in vivo</i> aktivierbar ist, umfassend eine zentrale Region mit spezifischer biologischer Aktivität, an dessen C-terminalem Ende sich eine Region mit einer Prozessierungseinheit und einer Inhibitordomäne befindet, während sich am N-terminalen Ende eine Region befindet, die ein Makromolekül auf einer Zelloberfläche oder eine Komponente der extrazellulären Matrix selektiv erkennt.

IPC 1-7 (main, further and additional classification)

C12N 15/62; A61K 47/48; C07K 19/00; C12N 1/21; C12N 5/10; C12N 15/63

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/525 (2006.01); C07K 14/715 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01); C07K 16/46 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12P 21/02 (2006.01)

CPC (invention and additional information)

C07K 16/40 (2013.01); A61K 47/6849 (2017.08); C07K 14/525 (2013.01); C07K 14/7151 (2013.01); C07K 2317/24 (2013.01); C07K 2317/622 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 0222833A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0222833 A1 20020321; AU 9381901 A 20020326; BG 107613 A 20031231; BR 0113928 A 20030722; CA 2422759 A1 20030317; CN 1214115 C 20050810; CN 1458977 A 20031126; DE 10045592 A1 20020328; EE 200300100 A 20050215; EP 1317556 A1 20030611; HR P20030192 A2 20051031; HU 0301693 A2 20030828; HU 0301693 A3 20051128; IL 154185 D0 20030731; JP 2004508828 A 20040325; KR 20030048041 A 20030618; MX PA03002229 A 20050620; NO 20031185 A 20030505; NO 20031185 D0 20030314; PL 360540 A1 20040906; RU 2003106429 A 20040827; SK 2812003 A3 20031104; US 2004053829 A1 20040318; YU 18903 A 20060525; ZA 200302008 B 20040625

INPADOC legal status


2009-05-27 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20081202

2006-09-13 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20060816

2003-08-13 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: PFIZENMAIER, KLAUS

2003-08-13 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: WUEST, THOMAS

2003-08-13 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: MOOSMAYER, DIETER

2003-08-13 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: GRELL, MATTHIAS

2003-08-13 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: SCHEURICH, PETER

2003-06-11 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20030130

2003-06-11 [AK] DESIGNATED CONTRACTING STATES:

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2003-06-11 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Countries: AL LT LV MK RO SI