Global Patent Index - EP 1319070 A2

EP 1319070 A2 2003-06-18 - MAMMALIAN RECEPTOR GENES AND USES

Title (en)

MAMMALIAN RECEPTOR GENES AND USES

Title (de)

SÄUGER-REZEPTORGENE UND VERWENDUNGEN DAVON

Title (fr)

GENES DE RECEPTEURS MAMMALIENS ET LEURS UTILISATIONS

Publication

EP 1319070 A2 (EN)

Application

EP 01972993 A

Priority

  • US 0128455 W
  • US 65951900 A
  • US 30396701 P

Abstract (en)

[origin: WO0222801A2] The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian trace amine receptor proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian trace amine receptor gene. Also provided are recombinant expression constructs capable of expressing the mammalian trace amine receptor genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian trace amine receptor proteins encoded therein. The invention also provides methods for screening compounds <i>in vitro</i> that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A61K 31/13; A61P 9/12; A61P 11/06; A61P 25/18; A61P 25/24; A61P 25/30; A61P 29/00; C07K 14/705; C12Q 1/68; G01N 33/566

IPC 8 full level (invention and additional information)

A61P 9/12 (2006.01); A61P 11/06 (2006.01); A61P 25/18 (2006.01); A61P 25/24 (2006.01); A61P 25/30 (2006.01); A61P 29/00 (2006.01); C07K 14/72 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 14/723 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 0222801A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0222801 A2 20020321; WO 0222801 A3 20030306; WO 0222801 A9 20030703; AU 9261701 A 20020326; CA 2422288 A1 20020321; EP 1319070 A2 20030618

INPADOC legal status


2007-03-07 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20060909

2003-09-24 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030807

2003-06-18 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20030414

2003-06-18 [AK] DESIGNATED CONTRACTING STATES:

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2003-06-18 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Countries: AL LT LV MK RO SI