EP 1320368 A1 20030625 - INFUSION SOLUTIONS OF CIPROFLOXACIN HAVING REDUCED ACID CONTENT AND BEING STABLE IN STORAGE
Title (en)
INFUSION SOLUTIONS OF CIPROFLOXACIN HAVING REDUCED ACID CONTENT AND BEING STABLE IN STORAGE
Title (de)
LAGERSTABILE INFUSIONSLÖSUNG DES CIPROFLOXACINS MIT VERRINGERTEM SÄUREGEHALT
Title (fr)
SOLUTION POUR PERFUSION DE CIPROFLOXACINE STABLE AU STOCKAGE ET A TENEUR REDUITE EN ACIDE
Publication
Application
Priority
- DE 10048510 A 20000929
- EP 0111189 W 20010927
Abstract (en)
[origin: WO0226233A1] The invention relates to infusions of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid (ciprofloxacin) which are stable in storage and which can be obtained by mixing between 0.015 and 0.5 g of active ingredient for 100 ml of aqueous solution with sulphuric acid or sodium hydrogen sulfate in a quantity equal to or less than 0.96 mole per mole of active ingredient, sufficient for dissolving the active ingredient and stabilising the solution. The invention also relates to methods for producing the infusions and the use thereof. The inventive infusions enable the acid content to be reduced, are more stable in storage with the same acid content than other known solutions, and enable a larger proportion of secondary components to be tolerated in the active ingredient than previous standard infusions of ciprofloxacins.
IPC 1-7
IPC 8 full level
A61K 9/08 (2006.01); A61K 9/00 (2006.01); A61K 31/496 (2006.01); A61K 47/02 (2006.01); A61K 47/04 (2006.01); A61K 47/10 (2006.01); A61K 47/26 (2006.01); A61P 7/08 (2006.01)
CPC (source: EP KR US)
A61K 9/0019 (2013.01 - EP US); A61K 31/495 (2013.01 - KR); A61K 47/02 (2013.01 - EP US); A61P 7/08 (2017.12 - EP); A61P 31/04 (2017.12 - EP)
Citation (search report)
See references of WO 0226233A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0226233 A1 20020404; WO 0226233 B1 20020704; AU 1499302 A 20020408; BR 0114293 A 20030729; CA 2420556 A1 20030225; CN 1466457 A 20040107; DE 10048510 A1 20020516; EP 1320368 A1 20030625; HU P0302256 A2 20031128; IL 154509 A0 20030917; JP 2004509921 A 20040402; KR 20030068541 A 20030821; MX PA03002770 A 20041213; NO 20031411 D0 20030327; PL 360597 A1 20040920; SK 3322003 A3 20030701; US 2004082593 A1 20040429; ZA 200301459 B 20030827
DOCDB simple family (application)
EP 0111189 W 20010927; AU 1499302 A 20010927; BR 0114293 A 20010927; CA 2420556 A 20010927; CN 01816260 A 20010927; DE 10048510 A 20000929; EP 01983507 A 20010927; HU P0302256 A 20010927; IL 15450901 A 20010927; JP 2002530063 A 20010927; KR 20037004311 A 20030325; MX PA03002770 A 20010927; NO 20031411 A 20030327; PL 36059701 A 20010927; SK 3322003 A 20010927; US 38183903 A 20030911; ZA 200301459 A 20030224