EP 1320594 A2 20030625 - EXBB-EXBD-TONB GENE CLUSTER OF PSEUDOMONAS PUTIDA DOT-T1E CONFERRING TOLERANCE TO AROMATIC COMPOUNDS AND RESISTANCE TO ANTIBIOTICS
Title (en)
EXBB-EXBD-TONB GENE CLUSTER OF PSEUDOMONAS PUTIDA DOT-T1E CONFERRING TOLERANCE TO AROMATIC COMPOUNDS AND RESISTANCE TO ANTIBIOTICS
Title (de)
TOLERANZ GEGENÜBER AROMATISCHEN VERBINDUNGEN UND ANTIBIOTIKARESISTENZ VERLEIHENDE GENGRUPPE EXBB-EXBD-TONB AUS PSEUDOMONAS PUTIDA DOT-T1E
Title (fr)
PROCEDES DE PRODUCTION DE P-HYDROXYBENZOATE DANS DES BACTERIES
Publication
Application
Priority
- US 0131180 W 20010928
- US 23687900 P 20000930
Abstract (en)
[origin: WO0229034A2] This invention relates to the isolation of a novel tonB operon from <i>Pseudomonas putida</i>. These genes are useful to render the cells more sensitive to antibiotics, toluene, pHBA, aromatic compounds, parabenes, and aromatic amino acids after inactivation with specific mutant allels or more tolerant to these compounds after overexpression with appropriate expression vector. These findings are important in the field of medicine and biotechnology and biocatalysis. In addition a screen to identify pHBA tolerant genes is provided and strains with significant tolerance to pHBA were identified. These strains are important for pHBA production.
[origin: WO0229034A2] This invention relates to the isolation of a novel tonB operon from Pseudomonas putida. These genes are useful to render the cells more sensitive to antibiotics, toluene, pHBA, aromatic compounds, parabenes, and aromatic amino acids after inactivation with specific mutant allels or more tolerant to these compounds after overexpression with appropriate expression vector. These findings are important in the field of medicine and biotechnology and biocatalysis. In addition a screen to identify pHBA tolerant genes is provided and strains with significant tolerance to pHBA were identified. These strains are important for pHBA production.
IPC 1-7
IPC 8 full level
C07K 14/21 (2006.01); C12N 15/31 (2006.01); C12N 15/52 (2006.01); C12P 7/42 (2006.01)
CPC (source: EP US)
C07K 14/21 (2013.01 - EP US); C12N 15/52 (2013.01 - EP US); C12P 7/42 (2013.01 - EP US)
Citation (search report)
See references of WO 0229034A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0229034 A2 20020411; WO 0229034 A3 20030410; AP 2003002768 A0 20030331; AU 1302802 A 20020415; EA 200300426 A1 20040429; EP 1320594 A2 20030625; US 7348421 B1 20080325
DOCDB simple family (application)
US 0131180 W 20010928; AP 2003002768 A 20010928; AU 1302802 A 20010928; EA 200300426 A 20010928; EP 01981383 A 20010928; US 75464804 A 20040112