EP 1320623 A1 20030625 - PROMOTER SEQUENCES
Title (en)
PROMOTER SEQUENCES
Title (de)
PROMOTERSEQUENZEN
Title (fr)
SEQUENCES DE PROMOTEURS
Publication
Application
Priority
- SE 0102098 W 20010926
- SE 0003435 A 20000926
- SE 0004102 A 20001109
- US 23889700 P 20001010
Abstract (en)
[origin: WO0227008A1] The present invention relates to an isolated promoter region of the mammalian transcription factor FOXC2. The invention also relates to screening methods for agents modulating the expression of FOXC2 and thereby being potentially useful for the treatment of medical conditions related to obesity. The invention further relates to a previously unknown variant of the human FOXC2 gene, derived via the use of an alternative promoter, which produces an additional exon that generates a distinct open reading frame via splicing. The alternative gene encodes a variant of the FOXC2 transcription factor, which is lacking a part of the DNA-binding domain and consequently has a potential regulatory function.
IPC 1-7
IPC 8 full level
A61K 31/711 (2006.01); A61P 3/06 (2006.01); C07K 14/47 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12P 21/02 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
A61P 3/06 (2017.12); C12N 15/85 (2013.01); C12Q 1/6897 (2013.01); C12N 2830/001 (2013.01); C12N 2830/85 (2013.01); G01N 2500/00 (2013.01)
Citation (search report)
See references of WO 0227008A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0227008 A1 20020404; AU 9248101 A 20020408; CA 2421620 A1 20020404; EP 1320623 A1 20030625; JP 2004510417 A 20040408
DOCDB simple family (application)
SE 0102098 W 20010926; AU 9248101 A 20010926; CA 2421620 A 20010926; EP 01972843 A 20010926; JP 2002530771 A 20010926