EP 1320756 A1 20030625 - NOVEL ANTIBODY, IMMUNOASSAY AND METHOD FOR PROSTATE CANCER DETECTION
Title (en)
NOVEL ANTIBODY, IMMUNOASSAY AND METHOD FOR PROSTATE CANCER DETECTION
Title (de)
ANTIKÖRPER, IMMUNOASSAY UND VERFAHREN ZUM NACHWEIS VON PROSTATAKREBS
Title (fr)
NOUVEL ANTICORPS, DOSAGE IMMUNOLOGIQUE ET METHODE DE DETECTION DU CANCER DE LA PROSTATE
Publication
Application
Priority
- FI 0100834 W 20010926
- FI 20002127 A 20000927
Abstract (en)
[origin: WO0227323A1] This invention concerns an antibody wherein said antibody does bind with high affinity to human single-chain intact, i.e. not internally cleaved, mature and/or zymogen forms of prostate specific antigen (SCINT PSA). The antibody, obtainable through immunization with an uncleaved form of PSA and selected by its differential reactivity with the intact and internally cleaved forms, does not bind to a nicked PSA (PSA-N), wherein said PSA-N has been formed by internal peptide bond cleavage(s) of SCINT PSA resulting in two-chain or multi-chain PSA. This invention further concerns an immunoassay and a method for differentiating patients with cancer of the prostate (PCa) from patients with benign prostatic hyperplasia (BPH) and/or healthy male subjects without PCa, patients with aggressive PCa from patients with indolent PCa and/or patients with clinically localized and/or organ confined PCa from patients with extraprostatic extension of PCa and/or PCa with metastatic spread to lymph nodes or bone marrow using said antibody.
IPC 1-7
IPC 8 full level
G01N 33/531 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01); C12N 9/64 (2006.01); G01N 33/543 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP US)
C07K 16/40 (2013.01 - EP US); C12N 9/6445 (2013.01 - EP US); G01N 33/57434 (2013.01 - EP US)
Citation (search report)
See references of WO 0227323A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0227323 A1 20020404; AT E425460 T1 20090315; AU 9191101 A 20020408; DE 60137949 D1 20090423; EP 1320756 A1 20030625; EP 1320756 B1 20090311; ES 2322432 T3 20090622; FI 20002127 A0 20000927; JP 2004509934 A 20040402; JP 5254517 B2 20130807; US 2004101914 A1 20040527; US 7872104 B2 20110118
DOCDB simple family (application)
FI 0100834 W 20010926; AT 01972118 T 20010926; AU 9191101 A 20010926; DE 60137949 T 20010926; EP 01972118 A 20010926; ES 01972118 T 20010926; FI 20002127 A 20000927; JP 2002530851 A 20010926; US 38113203 A 20030721