EP 1322296 A1 20030702 - COLLOIDAL SUSPENSION OF SUBMICRONIC PARTICLES FOR CARRYING HYDROPHILIC ACTIVE PRINCIPLES (INSULIN) AND METHOD FOR PREPARING SAME
Title (en)
COLLOIDAL SUSPENSION OF SUBMICRONIC PARTICLES FOR CARRYING HYDROPHILIC ACTIVE PRINCIPLES (INSULIN) AND METHOD FOR PREPARING SAME
Title (de)
KOLLOIDALE SUSPENSION SUBMIKRONISCHER TEILCHEN DER VEKTORISATION AKTIVER HYDROPHILER PRINZIPIEN (INSULIN) UND DEREN HERSTELLUNG
Title (fr)
SUSPENSION COLLOIDALE DE PARTICULES SUBMICRONIQUES DE VECTORISATION DE PRINCIPES ACTIFS HYDROPHILES (INSULINE) ET LEUR MODE DE PREPARATION
Publication
Application
Priority
- FR 0103028 W 20011001
- FR 0012836 A 20001006
Abstract (en)
[origin: WO0228374A1] The invention concerns a suspension of particles for carrying hydrophilic active principles (insulin). Said carrier particles are based on a polyethylene glycol/hydrophobic neutral polyminoacid double-block polymer. Said polyethylene glycol/hydrophobic neutral polyaminoacid particles are associated with a hydrophilic active principle (insulin). The invention also concerns, a powdery solid from which the transporting particles are derived and the preparation of said solid and said suspension of transporting particles based on polyethylene glycol/hydrophobic neutral polyminoacid particles and insulin. Said preparation consists in copolymerising N-carboxy-anhydrides of hydrophobic neutral polyminoacid particles, in the presence of N-methyl/pyrrolidone, methanol, and amine-functionalised polyethylene glycol, thereby obtaining polyethylene glycol/hydrophobic neutral polyaminoacids, associating the latter with insulin; precipitating with water so as to obtain the carrier particles; optionally carrying out neutralisation, dialysis, concentration and elimination of water, thereby producing a powdery solid or suspended carrier particles and preparing pharmaceutical specialties.
IPC 1-7
IPC 8 full level
A61K 9/10 (2006.01); A61K 9/51 (2006.01); A61K 38/28 (2006.01); A61K 47/34 (2006.01); A61K 47/42 (2006.01); A61P 3/10 (2006.01)
CPC (source: EP KR US)
A61K 9/5146 (2013.01 - EP US); A61K 47/30 (2013.01 - KR); A61P 3/10 (2017.12 - EP)
Citation (search report)
See references of WO 0228374A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0228374 A1 20020411; AU 9393901 A 20020415; BR 0114513 A 20031021; CA 2424981 A1 20020411; CN 1468095 A 20040114; EP 1322296 A1 20030702; FR 2814951 A1 20020412; FR 2814951 B1 20030117; JP 2004510729 A 20040408; KR 20030048419 A 20030619; MX PA03002977 A 20041206; US 2004048782 A1 20040311
DOCDB simple family (application)
FR 0103028 W 20011001; AU 9393901 A 20011001; BR 0114513 A 20011001; CA 2424981 A 20011001; CN 01816893 A 20011001; EP 01974417 A 20011001; FR 0012836 A 20001006; JP 2002532199 A 20011001; KR 20037004651 A 20030401; MX PA03002977 A 20011001; US 39813303 A 20030401