EP 1323829 B1 20060531 - Method for the preparation of protected, enantiomerically enriched cyanohydrines by in-situ derivatisation
Title (en)
Method for the preparation of protected, enantiomerically enriched cyanohydrines by in-situ derivatisation
Title (de)
Verfahren zur Herstellung von geschützten, enantiomeren-angereicherten Cyanhydrinen durch in-situ-Derivatisierung
Title (fr)
Procédé de préparation de cyanohydrines pures et énantiomériquement enrichies par dérivatisation in-situ
Publication
Application
Priority
AT 20442001 A 20011228
Abstract (en)
[origin: EP1323829A2] Production of protected enantiomer-enriched cyanohydrins (I) comprises reacting an aldehyde or ketone (II) with a cyanoformate ester (III) in the presence of an (R)- or (S)-hydroxynitrile lyase in an organic, aqueous, 2-phase or emulsion medium at -5 to +40 degrees C. <??>Production of protected enantiomer-enriched cyanohydrins of formula NCC(R1)(R2)OC(O)OR3 (I) comprises reacting an aldehyde or ketone of formula R1C(O)R2 (II) with a cyanoformate ester of formula NCC(O)OR3 (III) in the presence of an (R)- or (S)-hydroxynitrile lyase in an organic, aqueous, 2-phase or emulsion medium at -5 to +40 degrees C. <??>R1, R2 = H or optionally substituted 1-20C alkyl, 5-20C aryl, 5-20C heteroaryl, 5-20C alkaryl, 5-20C alkylheteroaryl or 5-20C aralkyl; or <??>R1+R2 = optionally substituted 4-20C alkylene or heteroalkylene; and <??>R3 = optionally substituted 1-20C alkyl, 5-20C aryl or 5-20C heteroaryl; <??>provided that R1 and R2 are not both H.
IPC 8 full level
C12P 13/00 (2006.01); C12N 9/88 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP US)
C12P 13/004 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
EP 1323829 A2 20030702; EP 1323829 A3 20031210; EP 1323829 B1 20060531; AT 410792 B 20030725; AT A20442001 A 20021215; AT E328105 T1 20060615; CA 2415190 A1 20030628; DE 50206986 D1 20060706; ES 2262750 T3 20061201; JP 2003210187 A 20030729; US 2003129714 A1 20030710; US 6909011 B2 20050621
DOCDB simple family (application)
EP 02026849 A 20021129; AT 02026849 T 20021129; AT 20442001 A 20011228; CA 2415190 A 20021227; DE 50206986 T 20021129; ES 02026849 T 20021129; JP 2002380069 A 20021227; US 32592302 A 20021223