EP 1324763 A4 20071031 - STAT3 AGONISTS AND ANTAGONISTS AND THERAPEUTIC USES THEREOF
Title (en)
STAT3 AGONISTS AND ANTAGONISTS AND THERAPEUTIC USES THEREOF
Title (de)
STAT3-AGONISTEN UND ANTAGONISTEN UND IHRE THERAPEUTISCHEN ANWENDUNGSZWECKE
Title (fr)
AGONISTES ET ANTAGONISTES DE STAT3 ET APPLICATIONS THERAPEUTIQUES DE CEUX-CI
Publication
Application
Priority
- US 0128254 W 20010910
- US 23121200 P 20000908
Abstract (en)
[origin: WO0220032A1] The present invention relates to methods of modulating, <i>i.e.</i>, agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.
[origin: WO0220032A1] The present invention relates to methods of modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 38/17 (2006.01); A61K 38/20 (2006.01); C07K 14/47 (2006.01); G01N 33/50 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 38/1709 (2013.01); A61K 38/204 (2013.01); C07K 14/4705 (2013.01); G01N 33/5005 (2013.01); A61K 48/00 (2013.01)
Citation (search report)
- [X] WO 0044774 A2 20000803 - UNIV SOUTH FLORIDA [US]
- [PX] YAMAUCHI-TAKIHARA, K. & KISHIMOTO, T.: "A novel role for STAT3 in cardiac remodeling", TRENDS IN ARDIOVASCULAR MEDICINE, vol. 10, no. 7, October 2000 (2000-10-01), pages 298 - 303, XP002448914
- [X] NEGORO, S. ET AL.: "Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction", CARDIOVASCULAR RESEARCH, vol. 47, 6 September 2000 (2000-09-06), pages 797 - 805, XP002448915
- [PX] NEGORO, S. ET AL.: "Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxigenation-induced oxidative stress through the upregulation of manganese superoxide dismutase", CIRCULATION, vol. 104, 28 August 2001 (2001-08-28), pages 979 - 981, XP002448916
- See references of WO 0220032A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0220032 A1 20020314; WO 0220032 A9 20030320; CA 2421723 A1 20020314; EP 1324763 A1 20030709; EP 1324763 A4 20071031
DOCDB simple family (application)
US 0128254 W 20010910; CA 2421723 A 20010910; EP 01970740 A 20010910