Global Patent Index - EP 1324985 A4

EP 1324985 A4 20041006 - INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

Title (en)

INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

Title (de)

HEMMSTOFFE DER PRENYL-PROTEIN TRANSFERASE

Title (fr)

INHIBITEURS DE LA PRENYL-PROTEINE TRANSFERASE

Publication

EP 1324985 A4 20041006 (EN)

Application

EP 01979912 A 20010928

Priority

  • US 0142389 W 20010928
  • US 23724100 P 20001002

Abstract (en)

[origin: WO0228831A1] The present invention is directed to fused bicyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

IPC 1-7

C07D 209/12; A61K 31/4045; C07D 401/12; C07D 471/04; C07D 209/18; C07D 401/14; C07D 405/12; C07D 403/12; C07D 401/04; A61P 35/00

IPC 8 full level

C07D 401/04 (2006.01); A61K 31/337 (2006.01); A61K 31/405 (2006.01); A61K 31/4155 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/497 (2006.01); A61K 31/506 (2006.01); A61K 41/00 (2006.01); A61K 45/00 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 15/00 (2006.01); A61P 27/02 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 43/00 (2006.01); C07D 209/18 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 471/04 (2006.01)

CPC (source: EP)

A61P 3/10 (2017.12); A61P 9/10 (2017.12); A61P 13/12 (2017.12); A61P 15/00 (2017.12); A61P 27/02 (2017.12); A61P 31/10 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 43/00 (2017.12); C07D 209/18 (2013.01); C07D 401/06 (2013.01); C07D 405/12 (2013.01); C07D 471/04 (2013.01)

Citation (search report)

  • [X] US 3314964 A 19670418 - SHAVEL JR JOHN, et al
  • [X] WO 9204321 A1 19920319 - RHONE POULENC RORER INT [US]
  • [X] WO 9801428 A1 19980115 - DU PONT MERCK PHARMA [US]
  • [X] US 4656182 A 19870407 - HORWELL DAVID [GB]
  • [PX] JP 2001089448 A 20010403 - YAMANOUCHI PHARMA CO LTD
  • [PX] WO 0155107 A2 20010802 - MELACURE THERAPEUTICS AB [SE], et al
  • [X] TETRAHEDRON LETT., vol. 25, no. 14, 1984, pages 1513 - 1516, XP002291110
  • [PX] CHEM. COMM., 2001, pages 209 - 210, XP002291111
  • [PX] TROTTER B W ET AL: "2-Arylindole-3-acetamides - FPP-Competitive inhibitors of farnesyl protein transferase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 11, no. 7, 9 April 2001 (2001-04-09), pages 865 - 869, XP004232512, ISSN: 0960-894X
  • See references of WO 0228831A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0228831 A1 20020411; AU 1182802 A 20020415; CA 2424222 A1 20020411; EP 1324985 A1 20030709; EP 1324985 A4 20041006; JP 2004510762 A 20040408

DOCDB simple family (application)

US 0142389 W 20010928; AU 1182802 A 20010928; CA 2424222 A 20010928; EP 01979912 A 20010928; JP 2002532417 A 20010928