Title (en)

NOVEL AMINOTRIAZOLONE COMPOUNDS, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Title (de)

AMINOTRIAZOLON-VERBINDUNGEN, VERFAHREN ZU DEREN HERSTELLUNG UND SIE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN

Title (fr)

NOUVEAUX COMPOSES AMINOTRIAZOLONES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT

Publication

EP 1324998 A1 20030709 (FR)

Application

EP 01978526 A 20011011

Priority

• FR 0103133 W 20011011
• FR 0013125 A 20001013

Abstract (en)

[origin: FR2815346A1] Aminotriazolone derivatives (I) their enantiomers, diastereoisomers, and salts with acids and bases are new. Aminotriazolone derivatives (I) their enantiomers, diastereoisomers, and salts with acids and bases: R1 and R2 = H, 1-6C alkyl, 1-6C alkenyl, 1-6C alkynyl, aryl, heteroaryl, 3-8C cycloalkyl or heterocycloalkyl (all optionally substituted by OH, cycloalkyl, aryl, heteroaryl, heterocycloalkyl or halo); aryl = phenyl, naphthyl, biphenyl, dihydronaphthyl or tetrahydronaphthyl; R3 = H, 1-6C alkyl, 1-6C alkenyl, 1-6C alkynyl, aryl, heteroaryl ( mono- or bicyclic with 0-4 heteroatoms), 3-8C cycloalkyl or heterocycloalkyl (mono- or bicyclic with 0-4 heteroatoms) (all optionally substituted by OH, cycloalkyl, aryl, heteroaryl, heterocycloalkyl or halo); R4 = a group of formula (II); W = a bond or 1-6C alkylene; B = 3-10 membered mono- or polycyclic group (may be aromatic (optionally substituted by alkyl, alkoxy, halogen, OH, perhaloalkyl, NO2, amino (optionally substituted, acyl, aminocarbonyl, acylamino, alkoxycarbonyl, formyl, carboxy, sulfo, sulfino, sulfamoyl, nitrile, aminoalkyl, thioalkyl, or hydroxyalkyl) and may contain 1-3 hetero atoms (O, N, S) and contains at least one oxo), -COR or hydroxy group (may contain one or more unsaturations and one or more substituents (alkyl, alkoxy, OH, aryl, aralkyl, halo)); R = H, 1-6C alkyl, alkoxy, amino, alkylamino or dialkylamino; R5 = H or 1-6C alkyl; A = -A2-, -A1-A2-, -A2-A1- or -A1-A2-A1-; A1 = 1-6C alkylene, 1-6C alkenylene or 1-6C alkynylene; A2 = phenylene, naphthylene, 3-8C cycloalkylene, heteroarylene or heterocyclalkylene (all of which may be substituted by OH, cycloalkyl, aryl, heteroaryl, heterocycloalkyl or halo); V = a bond, -CH2-, -CO-, -CS-, -CH2NH- or -CH=N-; or V+R3 with -A- + -NR4- = -A-CH=N-R4. Provided that only one of R1 and R2 may be H.

IPC 1-7

C07D 405/12; C07D 409/12; C07D 405/14; C07D 413/12; C07D 403/12; C07D 401/12; C07D 249/14; C07D 417/12; A61K 31/4196; A61P 9/12

IPC 8 full level

A61K 31/4196 (2006.01); A61K 31/422 (2006.01); A61K 31/428 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/55 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 9/12 (2006.01); C07D 249/14 (2006.01); A61P 15/10 (2006.01); A61P 25/08 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 43/00 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 417/04 (2006.01)

CPC (source: EP KR US)

A61P 1/00 (2018.01 - EP); A61P 3/00 (2018.01 - EP); A61P 3/04 (2018.01 - EP); A61P 3/08 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 9/12 (2018.01 - EP); A61P 15/10 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/08 (2018.01 - EP); A61P 25/20 (2018.01 - EP); A61P 25/22 (2018.01 - EP); A61P 25/24 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 401/12 (2013.01 - EP US); C07D 403/12 (2013.01 - EP US); C07D 405/12 (2013.01 - EP KR US); C07D 405/14 (2013.01 - EP US); C07D 409/12 (2013.01 - EP US); C07D 413/12 (2013.01 - EP US)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

US 2004029875 A1 20040212; AR 031726 A1 20031001; AU 1063202 A 20020422; BR 0114632 A 20040217; CA 2424802 A1 20020418; CN 1468233 A 20040114; CZ 20031290 A3 20030813; EA 200300458 A1 20030828; EP 1324998 A1 20030709; FR 2815346 A1 20020419; FR 2815346 B1 20040220; HU P0302408 A2 20031229; JP 2004515475 A 20040527; KR 20030036929 A 20030509; MX PA03002956 A 20041213; NO 20031643 D0 20030410; NO 20031643 L 20030410; PL 360090 A1 20040906; SK 5712003 A3 20031104; WO 0230923 A1 20020418

DOCDB simple family (application)

US 39909803 A 20030411; AR P010104790 A 20011012; AU 1063202 A 20011011; BR 0114632 A 20011011; CA 2424802 A 20011011; CN 01817058 A 20011011; CZ 20031290 A 20011011; EA 200300458 A 20011011; EP 01978526 A 20011011; FR 0013125 A 20001013; FR 0103133 W 20011011; HU P0302408 A 20011011; JP 2002534309 A 20011011; KR 20037005208 A 20030412; MX PA03002956 A 20011011; NO 20031643 A 20030410; PL 36009001 A 20011011; SK 5712003 A 20011011