EP 1325123 A1 20030709 - INHIBITION OF STENOSIS OR RESTENOSIS BY P-SELECTIN ANTAGONISTS
Title (en)
INHIBITION OF STENOSIS OR RESTENOSIS BY P-SELECTIN ANTAGONISTS
Title (de)
STENOSE- BZW. RESTENOSEHEMMUNG DURCH P-SELECTIN-ANTAGONISTEN
Title (fr)
INHIBITION DE LA STENOSE OU DE LA RESTENOSE AU MOYEN D'ANTAGONISTESDE LA P-SELECTINE
Publication
Application
Priority
US 0025007 W 20000912
Abstract (en)
[origin: WO0222820A1] The present invention relates to methods and compositions for the modulation of restenosis and stenosis characterized by constrictive vascular remodeling and neointimal formation, in a subject, by administering a P-selectin antagonist. The invention further provides methods for modulating leukocyte recruitment, cell to cell adhesion, and cell adhesion to blood vessels in a subject by administering soluble P-selectin ligand, an anti-P-selectin ligand antibody, or an anti-P-selectin antibody. The invention also provides methods for identifying compounds capable of modulating restenosis.
IPC 1-7
IPC 8 full level
C07K 14/705 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/705 (2013.01); C07K 14/70564 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0222820 A1 20020321; AU 7480900 A 20020326; EP 1325123 A1 20030709; EP 1325123 A4 20040721
DOCDB simple family (application)
US 0025007 W 20000912; AU 7480900 A 20000912; EP 00963389 A 20000912