EP 1326600 A2 20030716 - MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO
Title (en)
MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO
Title (de)
VERMITTLERSUBSTANZEN VON "IGEL"-SIGNALWEGEN, ENTSPRECHENDE ZUSAMMENSETZUNGEN UND VERWENDUNGEN
Title (fr)
MEDIATEURS DE VOIES DE SIGNALISATION DE HEDGEHOG, COMPOSITIONS ET UTILISATIONS ASSOCIEES
Publication
Application
Priority
- US 0132054 W 20011012
- US 24053600 P 20001013
Abstract (en)
[origin: CA2424785A1] The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of function, ptc loss-of - function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
IPC 1-7
IPC 8 full level
A61K 47/10 (2006.01); A61K 31/40 (2006.01); A61K 31/4025 (2006.01); A61K 31/4465 (2006.01); A61K 31/496 (2006.01); A61K 31/551 (2006.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 31/40 (2013.01); A61K 31/4025 (2013.01)
Citation (search report)
See references of WO 0230421A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
AU 1171302 A 20020422; CA 2424785 A1 20020418; EP 1326600 A2 20030716; JP 2004531458 A 20041014
DOCDB simple family (application)
AU 1171302 A 20011012; CA 2424785 A 20011012; EP 01979788 A 20011012; JP 2002533862 A 20011012