EP 1326605 A1 20030716 - METHODS FOR INHIBITING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS
Title (en)
METHODS FOR INHIBITING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS
Title (de)
VERWENDUNG VON HEMMSTOFFEN DER BINDUNG VON LEUKOTRIEN B4 AN DEN LEUKOTRIEN B4 REZEPTOR ZUR HEMMUNG DER PROLIFERATION UND ZUR INDUKTION DER APOPTOSE IN KREBSZELLEN
Title (fr)
PROCEDES SERVANT A INHIBER LA PROLIFERATION ET A INDUIRE L'APOPTOSE DANS DES CELLULES CANCEREUSES
Publication
Application
Priority
- US 0140697 W 20010508
- US 21934400 P 20000509
Abstract (en)
[origin: WO0185166A1] Disclosed are methods of decreasing proliferation of adenocarcinoma cancer cells, or of inducing apoptosis of adenocarcinoma cancer cells, or of inducing differentiation of adenocarcinoma cancer cells into non-cancerous cells. One such method includes contacting the adenocarcinoma cancer cells with a compound under conditions effective for the compound to inhibit binding of leukotriene B4 to leukotriene B4 receptor. In another such method, the method includes contacting the adenocarcinoma cancer cells with 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid or a pharmaceutically acceptable salt, solvate, or congener thereof. Also disclosed are methods of treating adenocarcinomas in a subject. One method includes administering to the subject an amount of a compound effective to inhibit binding of leukotriene B4 to leukotriene B4 receptor. Another method includes administering 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluoropheyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid or a pharmaceutically acceptable salt, solvate, or congener thereof, to the subject.
IPC 1-7
A61K 31/41; A61K 31/194; A61K 31/352; A61K 31/44; A61K 31/445; A61K 38/00
IPC 8 full level
A61K 45/00 (2006.01); A61K 31/00 (2006.01); A61K 31/192 (2006.01); A61K 31/194 (2006.01); A61K 31/352 (2006.01); A61K 31/41 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP KR)
A61K 31/00 (2013.01 - EP); A61K 31/192 (2013.01 - EP); A61K 31/41 (2013.01 - EP KR); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0185166 A1 20011115; AU 6183201 A 20011120; BR 0110473 A 20030401; CA 2408622 A1 20011115; CN 1237968 C 20060125; CN 1429111 A 20030709; EP 1326605 A1 20030716; EP 1326605 A4 20040317; JP 2003532675 A 20031105; KR 20030019372 A 20030306; MX PA02010974 A 20040906; NO 20025343 D0 20021107; NO 20025343 L 20030109; NZ 522387 A 20030926
DOCDB simple family (application)
US 0140697 W 20010508; AU 6183201 A 20010508; BR 0110473 A 20010508; CA 2408622 A 20010508; CN 01809329 A 20010508; EP 01935770 A 20010508; JP 2001581820 A 20010508; KR 20027015033 A 20021108; MX PA02010974 A 20010508; NO 20025343 A 20021107; NZ 52238701 A 20010508