EP 1328661 A2 20030723 - ESTROGEN RECEPTOR ALPHA VARIANTS AND METHODS OF DETECTION THEREOF
Title (en)
ESTROGEN RECEPTOR ALPHA VARIANTS AND METHODS OF DETECTION THEREOF
Title (de)
ÖSTROGENREZEPTOR ALPHA VARIANTEN UND METHODEN ZU DEREN DETEKTION
Title (fr)
VARIANTS ALPHA DU RECEPTEUR D'OESTROGENE ET TECHNIQUES DE DETECTION DE CES VARIANTS
Publication
Application
Priority
- US 0125990 W 20010821
- US 69241400 A 20001020
- US 76818401 A 20010124
- US 80407601 A 20010313
- US 82631401 A 20010405
Abstract (en)
[origin: WO0234945A2] The present invention is based on sequencing genomic DNA from human chromosome 6 and cDNAs to define the genomic structure of estrogen receptor alpha genes and novel polymorphism/haplotypes in the estrogen receptor gene/protein. Such polymorphism/haplotypes can lead to a variety of disorders that are mediated/modulated by a variant estrogen receptor, such as a susceptibility to cancer, osteoporosis, cardiovascular disorder, etc. Based on this sequencing approach, the present invention provides genomic nucleotide sequences, cDNA sequences, amino acid sequences and sequence polymorphism/haplotypes in the ESR-alpha genes, methods of detecting these sequences/polymorphism/haplotypes in a sample, methods of determining a risk of having or developing a disorder mediated by a variant estrogen receptor and methods of screening for compounds used to treat disorders mediated by a variant estrogen receptor.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); C07K 14/705 (2006.01); C07K 14/72 (2006.01); C07K 16/28 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/566 (2006.01)
CPC (source: EP)
C07K 14/70567 (2013.01); C12Q 1/68 (2013.01)
Citation (search report)
See references of WO 0234945A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0234945 A2 20020502; WO 0234945 A3 20020808; AU 8656001 A 20020506; CA 2426405 A1 20020502; EP 1328661 A2 20030723; JP 2004531228 A 20041014
DOCDB simple family (application)
US 0125990 W 20010821; AU 8656001 A 20010821; CA 2426405 A 20010821; EP 01966016 A 20010821; JP 2002560443 A 20010821