EP 1328813 A2 20030723 - A URINE TEST FOR THE DIAGNOSIS OF PRION DISEASES
Title (en)
A URINE TEST FOR THE DIAGNOSIS OF PRION DISEASES
Title (de)
DIAGNOSE VON PRIONERKRANKUNGEN IN EINER URINPROBE
Title (fr)
ANALYSE D'URINE SERVANT A DIAGNOSTIQUER DES MALADIES A PRION
Publication
Application
Priority
- IL 0100968 W 20011021
- IL 13918500 A 20001022
- IL 14195001 A 20010312
Abstract (en)
[origin: WO0233420A2] The present invention relates to a method for detecting the presence of the abnormal isoform of prion protein (PrPSC) in a urine sample of a subject. The method of the invention comprising the steps of: (a) providing a urine sample of said subject; (b) isolating from said sample all proteins, preferably, isolating proteins having a molecular weight higher than about 8 Kda; (c) optionally, and preferably, subjecting the proteins obtained in step (b) to protease digestion, and isolating from the mixture obtained in step (c) any protease resistant proteins; and (d) detecting the presence of PrPSC in the protease resistant fraction obtained in step (c) by a suitable detection technique.Furthermore, the invention further relates to methods for diagnosing a prion disease in a subject and for screening donors of blood samples for the presence of prion diseases. The invention further provides for a diagnostic kit for diagnosing a prion disease in a subject.
IPC 1-7
IPC 8 full level
C12Q 1/37 (2006.01); G01N 27/447 (2006.01); G01N 33/493 (2006.01); G01N 33/577 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
G01N 33/6896 (2013.01 - EP US); G01N 2333/4709 (2013.01 - EP US); G01N 2800/2828 (2013.01 - EP US)
Citation (search report)
See references of WO 0233420A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0233420 A2 20020425; WO 0233420 A3 20030103; AR 031270 A1 20030917; AU 1264702 A 20020429; BR 0115131 A 20040113; CA 2426126 A1 20020425; EP 1328813 A2 20030723; IL 141950 A0 20020310; JP 2004511809 A 20040415; NZ 525616 A 20041126; US 2005084983 A1 20050421
DOCDB simple family (application)
IL 0100968 W 20011021; AR P010104930 A 20011022; AU 1264702 A 20011021; BR 0115131 A 20011021; CA 2426126 A 20011021; EP 01980863 A 20011021; IL 14195001 A 20010312; JP 2002536556 A 20011021; NZ 52561601 A 20011021; US 39932104 A 20040211