Global Patent Index - EP 1332154 A4

EP 1332154 A4 20050511 - NOVEL THERAPEUTIC COMPOSITIONS FOR TREATING INFECTION BY LAWSONIA SPP

Title (en)

NOVEL THERAPEUTIC COMPOSITIONS FOR TREATING INFECTION BY LAWSONIA SPP

Title (de)

THERAPEUTISCHE ZUSAMMENSETZUNG ZUR BEHANDLUNG EINER LAWSONIA SSP INFEKTION(21.05.02)

Title (fr)

NOUVELLES COMPOSITIONS THERAPEUTIQUES POUR TRAITER UNE INFECTION PAR LAWSONIA SPP

Publication

EP 1332154 A4 20050511 (EN)

Application

EP 01983297 A 20011109

Priority

  • AU 0101462 W 20011109
  • AU PR138100 A 20001110
  • US 24959600 P 20001117

Abstract (en)

[origin: WO0238594A1] The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by <i>Lawsonia intracellularis</i> or similar or otherwise related microorganisms. In particular, the present invention provides a novel gene derived from <i>Lawsonia intracellularis</i>, which encodes an immunogenic polypeptide that is particularly useful as an antigen in a vaccine preparation for conferring humoral immunity against <i>Lawsonia intracellularis</i> and related pathogens in animal hosts, wherein said polypeptide is selected from the group consisting of flhB, fliR, ntrC, glnH, motA, motB, tlyC, ytfM, and ytfN polypeptides, or a homologue, analogue or derivative of any one or more of said polypeptides. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting <i>Lawsonia intracellularis</i> or similar or otherwise related microorganisms.

IPC 1-7

C07K 14/195; C07K 16/12; C12N 15/31; A61K 39/02; A61P 1/00; G01N 33/537; C12Q 1/04

IPC 8 full level

G01N 33/53 (2006.01); A61K 39/02 (2006.01); A61P 1/00 (2006.01); A61P 31/04 (2006.01); C07K 14/195 (2006.01); C07K 14/205 (2006.01); C07K 16/12 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12N 15/31 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/566 (2006.01); G01N 33/569 (2006.01); A61K 39/00 (2006.01)

CPC (source: EP)

A61P 1/00 (2018.01); A61P 31/04 (2018.01); C07K 14/195 (2013.01); C07K 14/205 (2013.01); A61K 39/00 (2013.01); A61K 2039/53 (2013.01)

Citation (search report)

  • [AD] WO 9720050 A1 19970605 - DARATECH PTY LTD [AU], et al
  • [X] WO 9958682 A2 19991118 - SMITHKLINE BEECHAM BIOLOG [BE], et al
  • [X] WO 0047737 A1 20000817 - SMITHKLINE BEECHAM BIOLOG [BE], et al
  • [X] EP 1001025 A2 20000517 - PFIZER PROD INC [US] & YANAGIHARA SHIGEHIRO ET AL: "Structure and transcriptional control of the flagellar master operon of Salmonella typhimurium", GENES AND GENETIC SYSTEMS, vol. 74, no. 3, June 1999 (1999-06-01), pages 105 - 111, XP002318057, ISSN: 1341-7568 & STAMM LOLA V ET AL: "Molecular characterization of a flagellar (fla) operon in the oral spirochete Treponema denticola ATCC 35405", FEMS MICROBIOLOGY LETTERS, vol. 179, no. 1, 1 October 1999 (1999-10-01), pages 31 - 36, XP002318058, ISSN: 0378-1097
  • [X] CARPENTER PHILLIP B ET AL: "Bacillus subtilis flagellar proteins FliP, FliQ, FliR and FlhB are related to Shigella flexneri virulence factors", GENE (AMSTERDAM), vol. 137, no. 2, 1993, pages 243 - 245, XP002306955, ISSN: 0378-1119
  • [A] DALE C JANE H ET AL: "Identification and sequencing of the groE operon and flanking genes of Lawsonia intracellularis: Use in phylogeny", MICROBIOLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 144, no. 8, August 1998 (1998-08-01), pages 2073 - 2084, XP002156652, ISSN: 1350-0872
  • [A] DATABASE EMBL 1 October 2000 (2000-10-01), TAKAMI ET AL.: "Flagellar biosynthetic protein fliR", XP002318060, Database accession no. Q9KA50
  • [X] PAWLOWSKI K ET AL: "CHARACTERIZATION OF A NOVEL AZORHIZOBIUM-CAULINODANS ORS571 TWO-COMPONENT REGULATORY SYSTEM NTRY-NTRX INVOLVED IN NITROGEN FIXATION AND METABOLISM", MOLECULAR AND GENERAL GENETICS, vol. 231, no. 1, 1991, pages 124 - 138, XP001205245, ISSN: 0026-8925
  • [X] STEGLITZ-MÖRSDORF U ET AL: "Cloning, heterologous expression, and sequencing of the Proteus vulgaris glnAntrBC operon and implications of nitrogen control on heterologous urease expression.", FEMS MICROBIOLOGY LETTERS. 15 JAN 1993, vol. 106, no. 2, 15 January 1993 (1993-01-15), pages 157 - 164, XP001205246, ISSN: 0378-1097
  • [A] DATABASE EMBL 1 October 2000 (2000-10-01), HEIDELBERG ET AL.: "Amino acid ABC transporter, periplasmic amino acid-binding protein.", XP002318061, Database accession no. Q9KKKR3
  • [PX] DATABASE EMBL 1 June 2001 (2001-06-01), FERRETTI ET AL.: "Hypothetical protein SPy1315.", XP002318062, Database accession no. Q99ZA4
  • [PX] DATABASE EMBL [online] 30 March 2001 (2001-03-30), "602541693F1 NIH_MGC_59 Homo sapiens cDNA clone IMAGE:4672631 5', mRNA sequence.", XP002318063, retrieved from EBI accession no. EM_PRO:BG495022 Database accession no. BG495022
  • [X] DEAN G E ET AL: "GENE SEQUENCE AND PREDICTED AMINO-ACID SEQUENCE OF THE MOT-A PROTEIN A MEMBRANE-ASSOCIATED PROTEIN REQUIRED FOR FLAGELLAR ROTATION IN ESCHERICHIA-COLI", JOURNAL OF BACTERIOLOGY, vol. 159, no. 3, 1984, pages 991 - 999, XP009044086, ISSN: 0021-9193
  • [X] DATABASE EMBL [online] 6 September 1996 (1996-09-06), "Vibrio parahaemolyticus lateral flagellin LafA (lafA), lateral flagellar FliD (fliD), lateral flagellar FliS (fliS), lateral flagellar FliT-like protein (fliT), lateral flagellar FliK-like protein (fliK), lateral flagellar FliL (fliL), lateral flagellar FliA (fliA), lateral flagellar MotA (motA), an", XP002318064, retrieved from EBI accession no. EM_PRO:VPU52957 Database accession no. VPU52957
  • [PX] DATABASE EMBL 1 March 2001 (2001-03-01), STOVER ET AL.: "Chemotaxis protein MotA", XP002318065, Database accession no. Q9HUL1
  • [X] DATABASE EMBL [online] 18 October 1999 (1999-10-18), "Salmonella typhimurium DNA for MotB protein, partial, MotA protein, FlhC protein, FlhD protein, UspA analogue.", XP002318066, retrieved from EBI accession no. EM_PRO:D43640 Database accession no. D43640
  • [X] DATABASE EMBL 1 November 1999 (1999-11-01), STAMM ET AL.: "Flagellar motor protein MotB (flagellar motor protein B)", XP002318067, Database accession no. Q9X5A1
  • [X] PLATZER J ET AL: "Three genes of a motility operon and their role in flagellar rotary speed variation in Rhizobium meliloti.", JOURNAL OF BACTERIOLOGY. OCT 1997, vol. 179, no. 20, October 1997 (1997-10-01), pages 6391 - 6399, XP002318059, ISSN: 0021-9193
  • [X] DATABASE UniProt [online] 15 July 1998 (1998-07-15), "Hypothetical UPF0053 protein sll1254.", XP002318068, retrieved from EBI accession no. UNIPROT:Y1254_SYNY3 Database accession no. Y1254_SYNY3
  • [X] DATABASE EMBL 1 November 1999 (1999-11-01), LEE ET AL: "Hypothetical protein", XP002318069, Database accession no. Q9X3V8
  • [PX] DATABASE EMBL 1 October 2001 (2001-10-01), KANEKO ET AL.: "Mll1662 protein.", XP002318070, Database accession no. Q98K30
  • [X] DATABASE EMBL 1 November 1999 (1999-11-01), LEE ET AL.: "Hypothetical protein", XP002318071, Database accession no. Q9X3V6
  • [PX] DATABASE EMBL 1 June 2001 (2001-06-01), NIERMAN ET AL.: "Hypothetical protein CC1604.", XP002318072, Database accession no. Q9A7W5
  • See also references of WO 0238594A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0238594 A1 20020516; WO 0238594 A9 20021107; BR 0114835 A 20030701; CA 2399276 A1 20020516; EP 1332154 A1 20030806; EP 1332154 A4 20050511; JP 2004512851 A 20040430; MX PA03003077 A 20030925; NZ 520600 A 20040827

DOCDB simple family (application)

AU 0101462 W 20011109; BR 0114835 A 20011109; CA 2399276 A 20011109; EP 01983297 A 20011109; JP 2002541925 A 20011109; MX PA03003077 A 20011109; NZ 52060001 A 20011109