EP 1333860 A4 20050810 - ANTIBODIES TO THE PROPEPTIDE OF CANDIDA ALBICANS AND METHODS OF USE
Title (en)
ANTIBODIES TO THE PROPEPTIDE OF CANDIDA ALBICANS AND METHODS OF USE
Title (de)
ANTIKÖRPER AUF DAS PROPEPTID VON CANDIDA ALBICANS UND METHODEN ZU IHRER VERWENDUNG
Title (fr)
ANTICORPS DU PROPEPTIDE DU CANDIDA ALBICANS ET SES PROCEDES D'UTILISATION
Publication
Application
Priority
- US 0130312 W 20010928
- US 23708200 P 20000928
Abstract (en)
[origin: WO0226257A1] Antibodies and agents which can bind to the propeptide of the Int1p protein of yeast microorganisms such as <i>Candida albicans</i> are provided which can be useful in methods for treating or preventing infections arising from such microorganisms. Microorganisms expressing the Int1p protein, such as <i>C. albicans</i> and <i>S. cerevisiae</i>, have shown an ability to immunomodulate host cells which allows infections of these microorganisms enhances to thrive and become virulent. In accordance with the present invention, peptide regions involved in the activation of the Int1p protein are isolated and targeted so as to provide a method of disrupting said activation and allow for treatment or prevention of infection by microorganisms expressing the int1p protein. In one preferred embodiment of the invention, an antibody or agent which can bind to the propeptide of the Int1P protein from <i>C. albicans</i> is utilized in methods to prevent or treat infections caused by <i>C. albicans</i> or other microorganisms expressing the Int1p protein.
IPC 1-7
IPC 8 full level
C12P 21/08 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61P 31/10 (2006.01); C07K 14/40 (2006.01); C07K 16/14 (2006.01); G01N 33/569 (2006.01)
CPC (source: EP)
A61P 31/10 (2017.12); C07K 16/14 (2013.01); G01N 33/56961 (2013.01); A61K 2039/505 (2013.01); G01N 2333/40 (2013.01)
Citation (search report)
- [X] US 5886151 A 19990323 - HOSTETTER MARGARET K [US], et al
- [X] GALE C A ET AL: "Linkage of adhesion, filamentous growth and virulence in candida albicans to a single gene, INT1", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 279, 27 February 1998 (1998-02-27), pages 1355 - 1358, XP002954887, ISSN: 0036-8075
- See references of WO 0226257A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0226257 A1 20020404; AU 1127902 A 20020408; CA 2423797 A1 20020404; EP 1333860 A1 20030813; EP 1333860 A4 20050810; JP 2004509923 A 20040402
DOCDB simple family (application)
US 0130312 W 20010928; AU 1127902 A 20010928; CA 2423797 A 20010928; EP 01979303 A 20010928; JP 2002530087 A 20010928