EP 1334100 A1 20030813 - BOMBESIN RECEPTOR ANTAGONISTS
Title (en)
BOMBESIN RECEPTOR ANTAGONISTS
Title (de)
BOMBESIN REZEPTOR ANTAGONISTEN
Title (fr)
ANTAGONISTES DU RECEPTEUR DE LA BOMBESINE
Publication
Application
Priority
- EP 0114401 W 20011116
- GB 0028104 A 20001117
Abstract (en)
[origin: GB2369117A] Novel bombesin receptor antagonists are provided which are useful for the diagnosis, prevention, or treatment of male sexual dysfunction in humans and animals, female sexual dysfunction in humans and animals, anxiety and panic disorders, social phobia, depression, psychoses, sleeping disorders, memory impairment, pulmonary hypertension, lung repair and lung development disorders, cancer including prostate cancer and pancreatic cancer, hepatic porphyria, gastrointestinal secretory disturbances, gastrointestinal disorders including colitis, Crohn's disease and inflammatory bowel disease, emesis, anorexia, pain, seasonal affective disorders, feeding disorders, or pruritus. The compounds of the invention are of the formula (I) or pharmaceutically acceptable salts thereof: <EMI ID=1.1 HE=29 WI=104 LX=616 LY=1460 TI=CF> <PC>wherein k, l, m, n, X, Ar, Ar<SP>1</SP>, R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP>, R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> are as defined in the description. Synthetic methods for the preparation of compounds of formula (I) and pharmaceutical compositions containing such compounds are disclosed.
IPC 1-7
C07D 401/12; A61K 31/4402; A61P 15/00; C07D 405/14; C07D 413/14; C07D 409/14; C07D 401/14; C07D 417/14
IPC 8 full level
A61K 31/4439 (2006.01); A61K 31/498 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 1/08 (2006.01); A61P 1/14 (2006.01); A61P 1/16 (2006.01); A61P 1/18 (2006.01); A61P 3/00 (2006.01); A61P 7/00 (2006.01); A61P 9/12 (2006.01); A61P 11/00 (2006.01); A61P 13/08 (2006.01); A61P 15/00 (2006.01); A61P 15/10 (2006.01); A61P 17/04 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01)
CPC (source: EP US)
A61P 1/00 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 1/08 (2017.12 - EP); A61P 1/14 (2017.12 - EP); A61P 1/16 (2017.12 - EP); A61P 1/18 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 13/08 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 15/10 (2017.12 - EP); A61P 17/04 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/12 (2013.01 - EP US); C07D 401/14 (2013.01 - EP US); C07D 405/14 (2013.01 - EP US); C07D 409/14 (2013.01 - EP US); C07D 413/14 (2013.01 - EP US); C07D 417/14 (2013.01 - EP US)
Citation (search report)
See references of WO 0240469A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
GB 0028104 D0 20010103; GB 2369117 A 20020522; AU 1607902 A 20020527; BR 0115414 A 20030909; CA 2426089 A1 20020523; EP 1334100 A1 20030813; JP 2004513945 A 20040513; MX PA03003892 A 20030728; US 2004116440 A1 20040617; WO 0240469 A1 20020523
DOCDB simple family (application)
GB 0028104 A 20001117; AU 1607902 A 20011116; BR 0115414 A 20011116; CA 2426089 A 20011116; EP 0114401 W 20011116; EP 01996536 A 20011116; JP 2002543480 A 20011116; MX PA03003892 A 20011116; US 41677903 A 20031204