EP 1337668 A2 20030827 - METHOD FOR DETECTING METHYLATION STATES FOR A TOXICOLOGICAL DIAGNOSTIC
Title (en)
METHOD FOR DETECTING METHYLATION STATES FOR A TOXICOLOGICAL DIAGNOSTIC
Title (de)
VERFAHREN ZUR DETEKTION VON METHYLIERUNGSZUSTÄNDEN ZUR TOXIKOLOGISCHEN DIAGNOSTIK
Title (fr)
PROCEDE DE DETECTION D'ETATS DE METHYLATION AFIN DE PERMETTRE LE DIAGNOSTIC TOXICOLOGIQUE
Publication
Application
Priority
- DE 10056802 A 20001114
- EP 0112951 W 20011108
Abstract (en)
[origin: WO0240710A2] The invention relates to a method for a toxicological diagnostic. According to the invention, a DNA sample is taken from an organism or a cell culture which has been exposed to a specific substance which is to be examined on account of its toxicological effect. The DNA contained in said sample is chemically pre-treated and the base sequence of a section of the modified DNA is determined. From there, a characteristic methylation state or a characteristic methylation model is determined for the sample. By comparison with data from methylation states of other samples, the effect of a substance on the organism or the cell culture is determined and/or compared to other substances in toxicological terms.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6883 (2018.01); G01N 33/50 (2006.01)
CPC (source: EP US)
C12Q 1/6883 (2013.01 - EP US); C12Q 2600/142 (2013.01 - EP US); C12Q 2600/154 (2013.01 - EP US); C12Q 2600/16 (2013.01 - EP US)
Citation (search report)
See references of WO 0240710A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0240710 A2 20020523; WO 0240710 A3 20030530; AU 2367202 A 20020527; DE 10056802 A1 20020529; DE 10056802 B4 20050616; EP 1337668 A2 20030827; JP 2004513650 A 20040513; US 2004048279 A1 20040311
DOCDB simple family (application)
EP 0112951 W 20011108; AU 2367202 A 20011108; DE 10056802 A 20001114; EP 01996625 A 20011108; JP 2002543021 A 20011108; US 41690503 A 20030514