EP 1339426 A4 20040630 - ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO TRAIL RECEPTORS
Title (en)
ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO TRAIL RECEPTORS
Title (de)
ANTIKÖRPER MIT IMMUNSPEZIFISCHER BINDUNG AN TRAIL-REZEPTOREN
Title (fr)
ANTICORPS A LIAISON IMMUNOSPECIFIQUE AVEC LES RECEPTEURS "TRAIL"
Publication
Application
Priority
- US 0142996 W 20011107
- US 24661200 P 20001108
- US 24884700 P 20001116
- US 25290400 P 20001127
- US 29501801 P 20010604
- US 32735901 P 20011009
Abstract (en)
[origin: WO02079377A2] The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptors. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TRAIL receptor antibodies, vectors, and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor.
IPC 1-7
IPC 8 full level
C07K 16/28 (2006.01)
CPC (source: EP)
C07K 16/2878 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/56 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01)
Citation (search report)
- [E] WO 0202641 A1 20020110 - HUMAN GENOME SCIENCES INC [US], et al
- [E] WO 0216436 A2 20020228 - NOVARTIS AG [CH], et al
- [Y] WO 9964461 A2 19991216 - GENENTECH INC [US]
- [YD] WO 9937684 A1 19990729 - GENENTECH INC [US]
- [AD] WO 9832856 A1 19980730 - HUMAN GENOME SCIENCES INC [US], et al
- [X] DATABASE EMBL [online] 3 October 2000 (2000-10-03), XP002277544, retrieved from EBI Database accession no. AAY93734
- [X] DATABASE EMBL [online] 2 August 2000 (2000-08-02), XP002277545, retrieved from EBI Database accession no. AAY82615
- [PX] DATABASE EMBL [online] 28 August 2001 (2001-08-28), XP002277565, retrieved from EBI Database accession no. AAB99378
- [X] DATABASE UNIPROT [online] 1 May 2000 (2000-05-01), XP002277546, retrieved from EBI Database accession no. Q9UL86
- [Y] GRIFFITH T S ET AL: "FUNCTIONAL ANALYSIS OF TRAIL RECEPTORS USING MONOCLONAL ANTIBODIES", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 162, no. 5, 1 March 1999 (1999-03-01), pages 2597 - 2605, XP000918935, ISSN: 0022-1767
- See references of WO 02079377A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02079377 A2 20021010; WO 02079377 A3 20030313; AU 2001297702 A1 20021015; CA 2426710 A1 20021010; EP 1339426 A2 20030903; EP 1339426 A4 20040630
DOCDB simple family (application)
US 0142996 W 20011107; AU 2001297702 A 20011107; CA 2426710 A 20011107; EP 01273517 A 20011107