EP 1341762 A1 20030910 - PROCESS FOR RESOLVING RACEMIC MIXTURES OF PIPERIDINE DERIVATIVES
Title (en)
PROCESS FOR RESOLVING RACEMIC MIXTURES OF PIPERIDINE DERIVATIVES
Title (de)
VERFAHREN ZUR RACEMATSPALTUNG VON PIPERIDINDERIVATEN
Title (fr)
PROCEDE DE DISSOLUTION DE MELANGES RACEMIQUES DE DERIVES DE PIPERIDINE
Publication
Application
Priority
- US 0142934 W 20011113
- US 24997100 P 20001120
Abstract (en)
[origin: WO02068391A1] A process for resolving a racemic mixture into its (R) and (S) enantiomers. The racemic mixture is reacted with a resolving agent selected from the group consisting of di-benzoyl-L-tartaric acid, di-benzoyl-D-tartaric acid, (S)-mandelic acid and (R)-mandelic acid in a solvent. The reaction is carried out under conditions sufficient to form soluble diastereomeric salts comprising the (R) enantiomer and the resolving agent, and the (S) enantiomer and the resolving agent, respectively. One of the diastereomeric salts is then isolated from the mixture. The free base of the isolated salt may then be generated in situ, and directly reacted with other compounds to synthesize useful chiral compounds.
IPC 1-7
IPC 8 full level
C07D 211/60 (2006.01)
CPC (source: EP)
C07D 211/60 (2013.01)
Citation (search report)
See references of WO 02068391A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02068391 A1 20020906; WO 02068391 A8 20031211; AU 2001297647 A1 20020912; EP 1341762 A1 20030910
DOCDB simple family (application)
US 0142934 W 20011113; AU 2001297647 A 20011113; EP 01273837 A 20011113