EP 1341915 A1 20030910 - USE OF CELLS DERIVED FROM EMBRYONIC STEM CELLS FOR INCREASING TRANSPLANTATION TOLERANCE AND FOR REPAIRING DAMAGED TISSUE
Title (en)
USE OF CELLS DERIVED FROM EMBRYONIC STEM CELLS FOR INCREASING TRANSPLANTATION TOLERANCE AND FOR REPAIRING DAMAGED TISSUE
Title (de)
VERWENDUNG VON AUS EMBRYONALEN STAMMZELLEN HERGELEITETEN ZELLEN ZUR ERHÖHUNG DER TRANSPLANTATIONSTOLERANZ UND ZUR WIEDERHERSTELLUNG ZERSTÖRTEN GEWEBES
Title (fr)
UTILISATION DE CELLULES DERIVEES DE CELLULES SOUCHES EMBRYONNAIRES POUR AUGMENTER LA TOLERANCE AUX TRANSPLANTATIONS ET POUR REGENERER UN TISSU ALTERE
Publication
Application
Priority
- DE 0104512 W 20011204
- DE 10061334 A 20001204
Abstract (en)
[origin: WO0246401A1] The invention relates to the use of cells from cell lines, which are derived from early embryonic stages, for the donor-specific increase in transplantation tolerance and for repairing damaged tissue. Areas of application of the invention include the field of medicine and the pharmaceutical industry. The aim of the invention is to produce a donor-specific immunotolerance in order to prevent a rejection of the transplanted tissue due to an immune response and thus to be able to limit the administration of immunosuppressives. In order to produce a donor-specific immunotolerance, embryonic stem cell-like cell lines (ECL) are obtained from blastocysts and are transfected with genetic material of the donor, which codes for the MHC haplotypes. The cells produced in such a manner are administered to the recipient before the transplantation for producing an immunotolerance against the tissue to be transplanted or for regenerating already damaged tissue.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A01K 67/027 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); A61P 1/16 (2006.01); A61P 9/04 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C07K 14/74 (2006.01); C12N 5/0735 (2010.01); C12N 5/10 (2006.01); C12N 15/12 (2006.01); C12N 15/85 (2006.01); A61K 35/12 (2015.01)
CPC (source: EP US)
A01K 67/0271 (2013.01 - EP US); A61K 39/001 (2013.01 - EP US); A61P 1/16 (2018.01 - EP); A61P 9/04 (2018.01 - EP); A61P 37/06 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 14/70539 (2013.01 - EP US); C12N 5/0606 (2013.01 - EP US); C12N 15/8509 (2013.01 - EP US); A01K 2217/05 (2013.01 - EP US); A01K 2227/105 (2013.01 - EP US); A01K 2267/025 (2013.01 - EP US); A01K 2267/03 (2013.01 - EP US); A01K 2267/0381 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US); A61K 2035/122 (2013.01 - EP US); A61K 2039/5156 (2013.01 - EP US); C12N 2510/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0246401 A1 20020613; DE 10061334 A1 20020613; EP 1341915 A1 20030910; JP 2004519437 A 20040702; US 2004208857 A1 20041021
DOCDB simple family (application)
DE 0104512 W 20011204; DE 10061334 A 20001204; EP 01995556 A 20011204; JP 2002548118 A 20011204; US 43355704 A 20040122