EP 1343434 A1 20030917 - METHODS FOR CONTEMPORANEOUS ADMINISTRATION OF LEVAMISOLE AND 5-FLUOROURACIL
Title (en)
METHODS FOR CONTEMPORANEOUS ADMINISTRATION OF LEVAMISOLE AND 5-FLUOROURACIL
Title (de)
VERFAHREN ZUR GLEICHZEITIGEN VERABREICHUNG VON LEVAMISOL UND 5-FLUOROURACIL
Title (fr)
PROCEDE D'ADMINISTRATION CONJUGUEE DE LEVAMISOLE ET DE 5-FLUOROURACILE
Publication
Application
Priority
- US 0146381 W 20011203
- US 25062900 P 20001201
Abstract (en)
[origin: WO0243618A1] The invention provides an improved method for potentiating the antineoplastic activity of 5-fluorouracil with levamisole, or with an analogue thereof. Specifically, the invention provides regimens wherein levamisole is administered contemporaneously with the administration of 5-fluorouracil, thereby increasing the exposure of tumor tissue to the simultaneous presence of the two drugs. The invention further provides methods for the parenteral administration of levamisole, thereby overcoming the disadvantages associated with inter-patient variability in the bioavailability of oral.
IPC 1-7
A61F 2/02; A61K 31/425; A61K 31/513; A61K 31/505; A61K 31/675; A61K 31/4745; A61K 31/337; A61K 31/282; A61P 35/00
IPC 8 full level
A61K 31/282 (2006.01); A61K 31/337 (2006.01); A61K 31/429 (2006.01); A61K 31/4545 (2006.01); A61K 31/513 (2006.01); A61K 31/519 (2006.01); A61K 31/675 (2006.01); A61K 31/704 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP)
A61K 31/429 (2013.01); A61K 31/513 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0243618 A1 20020606; AU 2002225902 B2 20060525; AU 2590202 A 20020611; CA 2430489 A1 20020606; EP 1343434 A1 20030917; EP 1343434 A4 20040818; JP 2004514683 A 20040520
DOCDB simple family (application)
US 0146381 W 20011203; AU 2002225902 A 20011203; AU 2590202 A 20011203; CA 2430489 A 20011203; EP 01995344 A 20011203; JP 2002545599 A 20011203