EP 1343796 A2 20030917 - COMPOUNDS AND METHODS
Title (en)
COMPOUNDS AND METHODS
Title (de)
VERBINDUNGEN UND METHODEN
Title (fr)
COMPOSES ET PROCEDES
Publication
Application
Priority
- US 0151175 W 20011023
- US 24242700 P 20001023
Abstract (en)
[origin: WO0234760A2] The invention relates to substituted urea compounds which are modulators, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, asthma and atopic disorders (for example atopic dermatitis and allergies), rheumatoid arthritis, sarcoidosis, or idiopathic pulmonary fibrosis and other fibrotic diseases, atherosclerosis, psoriasis, autoimmune diseases such as multiple sclerosis, treating and/or preventing rejection of transplanted organs, and inflammatory bowel disease, all in mammals, by the use of substituted urea compounds which are CCR5 receptor antagonists. Furthermore, since CD8+ T cells have been implicated in COPD, CCR5 may play a role in their recruitment and therefore antagonists to CCR5 could provide potential therapeutic in the treatment of COPD. Also since CCR5 is a co-receptor for the entry of HIV into cells, selective receptor modulators maybe useful in the treatment of HIV infection.
IPC 1-7
IPC 8 full level
C07D 209/44 (2006.01); C07D 209/62 (2006.01); C07D 215/08 (2006.01); C07D 217/06 (2006.01); C07D 223/16 (2006.01); C07D 223/32 (2006.01); C07D 401/12 (2006.01); C07D 413/04 (2006.01); C07D 491/10 (2006.01)
CPC (source: EP)
C07D 209/44 (2013.01); C07D 209/62 (2013.01); C07D 215/08 (2013.01); C07D 217/06 (2013.01); C07D 223/16 (2013.01); C07D 223/32 (2013.01); C07D 401/12 (2013.01); C07D 413/04 (2013.01); C07D 491/10 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0234760 A2 20020502; WO 0234760 A3 20030123; AU 3527702 A 20020506; EP 1343796 A2 20030917; EP 1343796 A4 20050112
DOCDB simple family (application)
US 0151175 W 20011023; AU 3527702 A 20011023; EP 01985647 A 20011023